PXD017220

PXD017220 is an original dataset announced via ProteomeXchange.

Title	Aspirin reshapes acetylomes in inflammatory and cancer cells via CoA-dependent and –independent pathways
Description	We used a deuterium-labeled aspirin (D-aspirin) together with mass spectrometry-based acetylomic analysis, termed “DAcMS”, to investigate the landscape of protein acetylation induced by aspirin. And we further demonstrated that aspirin acetylates proteins through both acetyl-CoA-dependent and -independent pathways, and the accessible lysine residues at the protein surface are major acetylation targets of aspirin.
HostingRepository	iProX
AnnounceDate	2020-01-21
AnnouncementXML	Submission_2020-11-18_21:07:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jing Gao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-21 00:58:06	ID requested
1	2020-01-21 01:03:34	announced
⏵ 2	2020-11-18 21:07:23	announced	2020-11-19: Update publication information

Guo L, Gao J, Gao Y, Zhu Z, Zhang Y, Aspirin Reshapes Acetylomes in Inflammatory and Cancer Cells via CoA-Dependent and CoA-Independent Pathways. J Proteome Res, 19(2):962-972(2020) [pubmed]

submitter keyword: Mass Spectrometry, Proteome, Aspirin, Acetylation, Acetylome

Yaoyang Zhang
contact affiliation	Shanghai Institute of Organic Chemistry
contact email	zyy@sioc.ac.cn
lab head
Jing Gao
contact affiliation	Shanghai Institute of Organic Chemistry
contact email	gaojing@sioc.ac.cn
dataset submitter

iProX dataset URI