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PXD017201

PXD017201 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIn-depth plasma proteomics in patients with metastatic cutaneous melanoma treated with immune checkpoint inhibitors or MAPK-inhibitors
DescriptionRecent development of new therapies with immune checkpoint inhibitors (ICIs) and MAPK-inhibitors (MAPKis) have significantly improved the outcome in metastatic cutaneous melanoma (CM). However, therapy response is limited to subgroups of patients and clinically useful predictive biomarkers for treatment outcome are lacking. To discover treatment-related systemic changes in plasma and potential biomarkers associated with treatment outcomes, we analysed 45 plasma samples from 24 patients with metastatic (stage IV) CM, using HiRIEF LC-MS/MS, collected before (pre-trm) and during treatment (trm). Of these, 27 samples were taken from 15 metastatic CM patients treated with ICIs (13 pre-trm and 14 trm samples; 12 matched) and 9 patients treated with MAPKis (9 matched). Matched samples were trm and pre-trm samples taken from the same individual before treatment and after the first cycle of treatment (before the second cycle). We have analysed the change in the plasma protein levels during treatment by comparing the plasma levels in the trm samples to the pre-trm samples, to detect treatment-induced alterations in the plasma proteome. We have analysed the patients treated with ICIs separately from the patients treated with MAPKis, to detect treatment-specific changes for both.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:08:47.316.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaris Babačić
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-20 06:03:30ID requested
12020-05-05 22:42:48announced
22024-10-22 05:08:50announced2024-10-22: Updated project metadata.
Publication List
10.1136/jitc-2019-000204;
Baba, č, i, ć H, Lehti, ö J, Pico de Coa, ñ, a Y, Pernemalm M, Eriksson H, In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma. J Immunother Cancer, 8(1):(2020) [pubmed]
Keyword List
submitter keyword: ipilimumab, MAPK-inhibitors,metastatic, plasma, MAPK, trametinib, programmed cell death protein 1, HiRIEF, immune checkpoint inhibitors, LC-MS/MS, nivolumab, dabrafenib, melanoma, vemurafenib, biomarkers
Contact List
Janne Lehtiö
contact affiliationDepartment of Oncology and Pathology, Karolinska Institute; Science for Life Laboratory, Stockholm, Sweden
contact emailjanne.lehtio@ki.se
lab head
Haris Babačić
contact affiliation1. Department of Oncology-Pathology, Karolinska Institute, Stockholm; 2. Proteogenomics Facility, Science for Life Laboratory
contact emailharis.babacic@ki.se
dataset submitter
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Dataset FTP location
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PRIDE project URI
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