PXD017079

PXD017079 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated multi-omic analysis of Mycobacterium tuberculosis isolates identifies ethionamide resistance-associated gene pair Rv3094c-Rv3095
Description	Global control of the tuberculosis (TB) epidemic is seriously threatened by increasing prevalence of drug resistant (DR) M. tuberculosis (MTB) isolates. Many genome-wide studies have identified DR-associated SNPs and investigated their role in DR mechanisms. However, DR in ~30% of isolates has no clear genetic basis. DR mechanisms related to variation in gene/protein expression are known, but not well-studied.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:07:35.602.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sun jinshuai
SpeciesList	scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-13 03:52:44	ID requested
1	2023-03-10 13:13:25	announced
⏵ 2	2023-11-14 08:07:37	announced	2023-11-14: Updated project metadata.

Publication List

Wan L, Hu P, Zhang L, Wang ZX, Fleming J, Ni B, Luo J, Guan CX, Bai L, Tan Y, Liu H, Li N, Xiao T, Bai H, Zhang YA, Zhang XE, Wan K, Bi L, Ouyang S, Zhang H, Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol, 6(1):156(2023) [pubmed]

Wan L, Hu P, Zhang L, Wang ZX, Fleming J, Ni B, Luo J, Guan CX, Bai L, Tan Y, Liu H, Li N, Xiao T, Bai H, Zhang YA, Zhang XE, Wan K, Bi L, Ouyang S, Zhang H, Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol, 6(1):156(2023) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: transcriptome,Mycobacterium tuberculosis, drug resistance, lineage, proteome, Baeyer-Villiger monooxygenase, phylogenetics, ethionamide, RNA-Seq

curator keyword: Biomedical

submitter keyword: transcriptome,Mycobacterium tuberculosis, drug resistance, lineage, proteome, Baeyer-Villiger monooxygenase, phylogenetics, ethionamide, RNA-Seq

Contact List

Kanglin Wan
contact affiliation	Chinese Center for Disease Control and Prevention
contact email	wankanglin@icdc.cn
lab head
Sun jinshuai
contact affiliation	Student
contact email	sjsshuai@126.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD017079
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD017079

PRIDE project URI

Repository Record List

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