PXD017065

PXD017065 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Tau posttranslational modifications
Description	Human tauopathies including Alzheimer's disease are characterized by alterations in the post-translational modification (PTM) pattern of Tau, leading to the formation of insoluble aggregates, neuronal dysfunction and degeneration. We immunoprecipitated Tau from post-mortem brain tissue of early stage Alzheimer's disease patients and age-matched controls, and analyzed PTMs on this soluble pool of Tau protein. In addition to known serine, threonine and tyrosine phosphorylation events, we identified a number of previously unknown monomethylation events on lysines in both control and Alzheimer's patient tissues.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-08_18:22:18.025.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dagmar Ehrnhoefer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; dimethylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-10 06:09:45	ID requested
⏵ 1	2021-09-08 18:22:18	announced

Publication List

Bichmann M, Prat Oriol N, Ercan-Herbst E, Sch, ö, ndorf DC, Gomez Ramos B, Schw, ä, rzler V, Neu M, Schl, ü, ter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE, SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Mol Neurodegener, 16(1):46(2021) [pubmed]

Bichmann M, Prat Oriol N, Ercan-Herbst E, Sch, ö, ndorf DC, Gomez Ramos B, Schw, ä, rzler V, Neu M, Schl, ü, ter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE, SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Mol Neurodegener, 16(1):46(2021) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: Alzheimer's disease, Tau, PTM, lysine methylation

curator keyword: Biomedical

submitter keyword: Alzheimer's disease, Tau, PTM, lysine methylation

Contact List

Dagmar E. Ehrnhoefer
contact affiliation	Neuroscience Discovery AbbVie Deutschland GmbH&Co. KG Knollstr. 50 67061 Ludwigshafen am Rhein Germany
contact email	dagmar.ehrnhoefer@abbvie.com
lab head
Dagmar Ehrnhoefer
contact affiliation	AbbVie Germany
contact email	dagmar.ehrnhoefer@abbvie.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD017065
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD017065

PRIDE project URI

Repository Record List

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