PXD017063

PXD017063 is an original dataset announced via ProteomeXchange.

Title	Identify the protein partners of Ercc1 in DNA damage progeria in MEFs
Description	ERCC1 is a DNA endonuclease participating in the Nucleotide Excision Repair (NER) pathway. Its functionality is related to XPF; the two proteins work as a heterodimer to incise the 5 of a 30-mer that contains the damaged nucleotide and remove the fragment together with XPG. Apart from NER deficiency, mutated Ercc1 in mice and humans causes a series of progeroid symptoms (premature ageing). We hypothesize that there are undescribed functions of ERCC1, possibly in transcriptional regulation that contribute to the development of the striking phenotypes observed. The aim is to identify previously uncharacterized protein partners of ERCC1 that might contribute to our understanding of its differential roles during DNA damage-driven progeria.
HostingRepository	PRIDE
AnnounceDate	2023-10-04
AnnouncementXML	Submission_2023-10-04_02:27:14.787.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD017063
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MichalisAivaliotis
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-10 05:49:49	ID requested
⏵ 1	2023-10-04 02:27:15	announced

10.6019/PXD017063;

submitter keyword: MEFs, XPF, proteomics, in vivo biotinylation tagging, Ercc1, DNA damage progeria, mouse, protein-protein interactions

MichalisAivaliotis
contact affiliation	IMBB-FORTH /AUTH
contact email	aivaliot@imbb.forth.gr
lab head
MichalisAivaliotis
contact affiliation	IMBB-FORTH/AUTH
contact email	aivaliot@imbb.forth.gr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017063
     1. Label: PRIDE project
     2. Name: Identify the protein partners of Ercc1 in DNA damage progeria in MEFs