PXD017062

PXD017062 is an original dataset announced via ProteomeXchange.

Title	The target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse docking, then, we. We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well with three potential target proteins.
Description	The results of this study demonstrated that esculetin can affect the glucose metabolism by binding to glycolytic proteins, thus playing an anti-tumor role, and the pathway comprising these proteins which have direct interactions are a potential novel targets for tumor treatment by esculetin.
HostingRepository	PRIDE
AnnounceDate	2020-01-20
AnnouncementXML	Submission_2020-01-20_00:56:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Songtao Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-10 05:47:51	ID requested
⏵ 1	2020-01-20 00:56:28	announced

Dataset with its publication pending

submitter keyword: HepG2, LC-MSMS

Songtao Wu
contact affiliation	Faculty of Pharmacy, Hubei University of Chinese Medicine
contact email	songt1wu@163.com
lab head
Songtao Wu
contact affiliation	Faculty of Pharmacy, Hubei University of Chinese Medicine
contact email	songt1wu@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD017062

PRIDE project URI

• PRIDE
  1. PXD017062
     1. Label: PRIDE project
     2. Name: The target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse docking, then, we. We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well with three potential target proteins.