PXD017008

PXD017008 is an original dataset announced via ProteomeXchange.

Title	Multi-omics analysis identifies ALDH7A1 as a key regulator of the visual-olfactory bimodal learning in honeybee
Description	Specific genes or encoded proteins are involved in regulating various learning models of different species through certain signaling pathways，but whether there are also regulatory genes during bimodal learning and memory is largely unknown. Using a multi-omics approach to examine gene expression changes in bees brain performed with three different learning assays, a general up-regulation of genes and proteins were observed in bimodal learning compared to controls. Protein-protein network predictions of differential proteins together with FISH assays suggest ALDH7A1 may be involved in regulation of bimodal learning and memory. Injecting siRNA-ALDH7A1 to the bee brain results in significant inhibition the expressions of ALDH7A1 and regucalcin, and increase β-alanine content. Interestingly, we found that loss of ALDH7A1 only affect visual-olfactory bimodal learning and memory, but not single visual or olfactory conditioned learning after ALDH7A1-RNAi in bees. Therefore, our data suggests that ALDH7A1 may affect bimodal learning and memory though controlling β-alanine related plasticity mechanisms.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:29:18.413.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	zhang yong
SpeciesList	scientific name: Apis mellifera (Honeybee); NCBI TaxID: 7460;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	4700 Proteomics Analyzer

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-08 03:34:13	ID requested
1	2021-09-12 17:32:04	announced
⏵ 2	2024-10-22 05:29:18	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological

submitter keyword: visual-olfactory bimodal learning

zhang yong
contact affiliation	jiangxi
contact email	973192832@qq.com
lab head
zhang yong
contact affiliation	86+18770910663
contact email	973192832@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017008
     1. Label: PRIDE project
     2. Name: Multi-omics analysis identifies ALDH7A1 as a key regulator of the visual-olfactory bimodal learning in honeybee