PXD017004 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphorylation regulates secretion of Mycobacterium tuberculosisvirulence mediators ESAT6 and CFP10 |
Description | Virulence effectors secreted by Mycobacterium tuberculosis help subvert host immune mechanisms and therefore are critical for establishment of infection and pathogenesis. However, knowledge in terms of signaling mechanisms thatmodulate the secretion of virulence factors is sparse. Here using high-throughput mass-spectrometric analysis of mycobacterial secretome,phospho-proteome and phospho-secretome combined with empirical validations, we show an unprecedented regulation of mycobacterial secretion via protein phosphorylation. The intricate relationship between phosphorylation and secretion was revealed by system-level analysis of PPI network superimposed with secretome and phospho-proteome profiles. This study establishes phosphorylation as a keydeterminant of secretion of virulence factors and unveils as yet unexplored targets for therapeutic interventions. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:03:23.186.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | basanti malakar |
SpeciesList | scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332; |
ModificationList | phosphorylated residue |
Instrument | LTQ Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-08 01:20:01 | ID requested | |
1 | 2023-09-18 05:27:10 | announced | |
⏵ 2 | 2024-10-22 06:03:23 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CFP10,Mycobacterium, Secretion, ESAT6, Phosphorylation |
Contact List
Vinay Kumar Nandicoori |
contact affiliation | Signal Transduction Lab 1, National Institute of Immunology, India |
contact email | vinaykn@nii.ac.in |
lab head | |
basanti malakar |
contact affiliation | National Institute of Immunology |
contact email | basantimalakar@nii.ac.in |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017004
- Label: PRIDE project
- Name: Phosphorylation regulates secretion of Mycobacterium tuberculosisvirulence mediators ESAT6 and CFP10