PXD016997
PXD016997 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of proteome changes in apoptotic NSCLC cells |
Description | Here, we used an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with their live counterparts. Among the multitude of proteins identified, some of them were represented as fragmented proteins in apoptotic tumor cells, and acted as non-mutated neoantigens. Only the fragmented proteins elicited effective multi-specific T cell responses, upon a chemotherapy protocol including CDDP. Importantly, these responses further increased significantly upon anti-PD-1 therapy, and correlated with patients’ survival and decreased PD-1 expression. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:06:08.192.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alessio Grimaldi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | 4800 Proteomics Analyzer |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-01-07 07:36:19 | ID requested | |
1 | 2020-05-26 17:12:52 | announced | |
⏵ 2 | 2024-10-22 05:06:09 | announced | 2024-10-22: Updated project metadata. |
Publication List
Grimaldi A, Cammarata I, Martire C, Focaccetti C, Piconese S, Buccilli M, Mancone C, Buzzacchino F, Berrios JRG, D'Alessandris N, Tomao S, Giangaspero F, Paroli M, Caccavale R, Spinelli GP, Girelli G, Peruzzi G, Nistic, ò P, Spada S, Panetta M, Letizia Cecere F, Visca P, Facciolo F, Longo F, Barnaba V, Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens. Commun Biol, 3(1):85(2020) [pubmed] |
10.1038/s42003-020-0811-x; |
Keyword List
curator keyword: Biomedical |
submitter keyword: LC-MSMS,NSCLC, SILAC |
Contact List
Vincenzo Barnaba | |
---|---|
contact affiliation | Dipartimento di Medicina Interna e Specialità Mediche |
contact email | vincenzo.barnaba@uniroma1.it |
lab head | |
Alessio Grimaldi | |
contact affiliation | Dip. Medicina interna e specialità mediche |
contact email | alessio.grimaldi@uniroma1.it |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD016997 |
PRIDE project URI |
Repository Record List
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