PXD016985 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and a Synucleinopathy Reveals Age- and Disease-Related Differences |
Description | The lack of appropriate protein biomarkers makes the early detection of Parkinson’s disease (PD) challenging, and it thwarts efforts to develop drug therapies for this incurable disease. Thus, new approaches are needed for biomarker discovery and for better understanding the molecular basis of PD progression. Here, we utilize proteome-wide measurements of protein folding stability to characterize the progression of PD in a mouse model of the disease in which the human α-synuclein protein with an A53T mutation was overexpressed. Using the Stability of Proteins from Rates of Oxidation (SPROX) technique, the thermodynamic stabilities of proteins in brain tissue cell lysates from Huα-Syn(A53T) transgenic mice were profiled at three time points including at 1 month (n=9), at 6 months (n=7), and at the time (between 9 and 16 months) a mouse became Symptomatic (n=8). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_10:35:08.621.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Renze Ma |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue |
Instrument | Q Exactive HF; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-07 04:49:43 | ID requested | |
⏵ 1 | 2024-10-07 10:35:09 | announced | |
Publication List
10.1021/acs.jproteome.1c00653; |
Ma R, Johnson JHR, Tang Y, Fitzgerald MC, -Synucleinopathy Reveals Age- and Disease-Related Differences. J Proteome Res, 20(11):5156-5168(2021) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Brain, Mouse,Parkinson's Disease |
Contact List
Michael Fitzgerald |
contact affiliation | Professor, Chemistry, Duke University |
contact email | michael.c.fitzgerald@duke.edu |
lab head | |
Renze Ma |
contact affiliation | Duke University |
contact email | renze.ma@duke.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016985
- Label: PRIDE project
- Name: Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and a Synucleinopathy Reveals Age- and Disease-Related Differences