PXD016978

PXD016978 is an original dataset announced via ProteomeXchange.

Title	Stimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication
Description	The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in various tumors promotes cell proliferation and invasiveness. The intracellular cellular pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by characterizing the the interactome of recombinant ACKR3 expressed in HEK293T cells. Among the ACKR3-interacting proteins identified, we focused on the gap junction protein Connexin 43 (Cx43).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:08:31.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oana Vigy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-07 03:25:19	ID requested
1	2020-07-07 04:29:35	announced
2	2020-10-19 01:49:48	announced	2020-10-19: Updated publication reference for PubMed record(s): 32978390.
⏵ 3	2024-10-22 05:08:34	announced	2024-10-22: Updated project metadata.

Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, S, é, veno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Sch, ü, tz D, Stumm R, Smit MJ, Gu, é, rineau NC, Chaumont-Dubel S, Marin P, The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun, 11(1):4855(2020) [pubmed]

10.1038/s41467-020-18634-y;

curator keyword: Biological

submitter keyword: chemiokines, Cx43,ACKR3, HEK293T

Philippe Marin
contact affiliation	Neuroproteomics and signaling of neurological and psychiatric disorders, IGF, France
contact email	Philippe.Marin@igf.cnrs.fr
lab head
Oana Vigy
contact affiliation	FPP CNRS
contact email	oana.vigy@fpp.cnrs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD016978

PRIDE project URI

• PRIDE
  1. PXD016978
     1. Label: PRIDE project
     2. Name: Stimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication