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PXD016978

PXD016978 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication
DescriptionThe atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in various tumors promotes cell proliferation and invasiveness. The intracellular cellular pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by characterizing the the interactome of recombinant ACKR3 expressed in HEK293T cells. Among the ACKR3-interacting proteins identified, we focused on the gap junction protein Connexin 43 (Cx43).
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:08:31.059.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterOana Vigy
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-07 03:25:19ID requested
12020-07-07 04:29:35announced
22020-10-19 01:49:48announced2020-10-19: Updated publication reference for PubMed record(s): 32978390.
32024-10-22 05:08:34announced2024-10-22: Updated project metadata.
Publication List
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, S, é, veno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Sch, ü, tz D, Stumm R, Smit MJ, Gu, é, rineau NC, Chaumont-Dubel S, Marin P, The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun, 11(1):4855(2020) [pubmed]
10.1038/s41467-020-18634-y;
Keyword List
curator keyword: Biological
submitter keyword: chemiokines, Cx43,ACKR3, HEK293T
Contact List
Philippe Marin
contact affiliationNeuroproteomics and signaling of neurological and psychiatric disorders, IGF, France
contact emailPhilippe.Marin@igf.cnrs.fr
lab head
Oana Vigy
contact affiliationFPP CNRS
contact emailoana.vigy@fpp.cnrs.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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