PXD016978 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Stimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication |
Description | The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in various tumors promotes cell proliferation and invasiveness. The intracellular cellular pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by characterizing the the interactome of recombinant ACKR3 expressed in HEK293T cells. Among the ACKR3-interacting proteins identified, we focused on the gap junction protein Connexin 43 (Cx43). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:08:31.059.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Oana Vigy |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-07 03:25:19 | ID requested | |
1 | 2020-07-07 04:29:35 | announced | |
2 | 2020-10-19 01:49:48 | announced | 2020-10-19: Updated publication reference for PubMed record(s): 32978390. |
⏵ 3 | 2024-10-22 05:08:34 | announced | 2024-10-22: Updated project metadata. |
Publication List
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, S, é, veno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Sch, ü, tz D, Stumm R, Smit MJ, Gu, é, rineau NC, Chaumont-Dubel S, Marin P, The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun, 11(1):4855(2020) [pubmed] |
10.1038/s41467-020-18634-y; |
Keyword List
curator keyword: Biological |
submitter keyword: chemiokines, Cx43,ACKR3, HEK293T |
Contact List
Philippe Marin |
contact affiliation | Neuroproteomics and signaling of neurological and psychiatric disorders, IGF, France |
contact email | Philippe.Marin@igf.cnrs.fr |
lab head | |
Oana Vigy |
contact affiliation | FPP CNRS |
contact email | oana.vigy@fpp.cnrs.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD016978 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016978
- Label: PRIDE project
- Name: Stimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication