PXD016938
PXD016938 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomics reveals the crucial roles of Cathepsin D in bacterial infections |
| Description | Bacterial resistance has become more and more widespread which seriously threatens human life and health. Therefore, using the natural immune system of host to kill bacteria is particularly fascinating. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of mitochondria and lysosomes proteins upon five kinds of bacteria (L. monocytogenes, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) infection in Macrophages cells. We showed that the protein expression level of Cathepsin D (CTSD) is up-regualated after bacterial infection. The knockout of CTSD indicated that, as a broad-spectrum antibacterial protein in the host, played an indispensable role in killing bacteria. Our study shows that CTSD can serve as a potential molecular drug target for antibacterial treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2020-05-13 |
| AnnouncementXML | Submission_2020-07-01_02:47:51.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiangbei Yuan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-01-05 17:13:53 | ID requested | |
| 1 | 2020-05-12 18:25:45 | announced | |
| ⏵ 2 | 2020-07-01 02:47:52 | announced | 2020-07-01: Update publication information. |
Publication List
| Fu Q, Yuan J, Wang L, Ran H, Li F, Liu F, Zhang J, Liu W, Huang W, Huang Y, Xia X, Proteomic analysis of murine macrophages mitochondria and lysosomes reveal Cathepsin D as a potential broad-spectrum antimicrobial protein. J Proteomics, 223():103821(2020) [pubmed] |
Keyword List
| submitter keyword: Cathepsin D (CTSD) Bacterial Infection Mitochondria and Lysosomes Proteins Mass Spectrometry |
Contact List
| Xuefeng Xia | |
|---|---|
| contact affiliation | Chongqing University |
| contact email | xxia@cqu.edu.cn |
| lab head | |
| Jiangbei Yuan | |
| contact affiliation | Chongqing University |
| contact email | yuanjiangbei@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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