Update publication information. Camelidae are inducing ovulators is tightly regulated by multiple factors, and understanding the biological mechanisms underlying follicular development, hormone secretion and ovulation requires investigation of the potential molecular pathways. However, little is known about the pathways of these factors in the camel. To identify candidate biomarkers of inducing ovulators, we performed a comprehensive proteomic and molecular biology analysis of the ovary from different groups. We identified 5,075 ovarian expressed proteins, of which 404 were differentially expressed (260 up-regulated, 144 down-regulated) in samples from treated versus control camels. Gene ontology annotation identified potential functions of the differentially expressed proteins (DEPs). We validated the differential expression for a subset of these proteins using qPCR, western blotting and immunofluorescence staining. Five DEPs (CAMK2G, FST, NR5A1, PAK1 and PRL) were involved in neurochemical signal transduction, endocrine and reproductive hormones regulatory processes. KEGG analysis indicated the involvement of several pathways, such as calcium, cAMP, gonadotropin-releasing hormone, MAPK, and neuroactive ligand-receptor signaling pathways, further suggesting that the induced ovulation process depends on the hypothalamic-pituitary-ovarian axis. We conclude that the profiling of ovarian proteomes, followed by the measurement of selected proteins using more targeted methods, offers a promising approach for studying the mechanisms of induced ovulation.