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PXD016846

PXD016846 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMass spectrometry-based characterization of Toxoplasma gondii MORC interactome
DescriptionT. gondii has a complex life cycle typified by an asexual development taking place in vertebrate, and a sexual reproduction which occurs exclusively in felids and thereby is less studied. The developmental transitions rely on changes in gene expression patterns, and recent studies have assigned roles for chromatin shapers, including histone modifications, in establishing specific epigenetic programs for each given stage. Here, we identified T. gondii microrchidia (MORC) protein as an upstream transcriptional repressor of sexual commitment. We performed affinity purification coupled to tandem mass spectrometry analyses to identify its binding partners.
HostingRepositoryPRIDE
AnnounceDate2020-01-09
AnnouncementXMLSubmission_2020-04-14_03:06:50.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD016846
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterYohann Cout��
SpeciesList scientific name: Toxoplasma gondii RH; NCBI TaxID: 383379; scientific name: Toxoplasma gondii PRU; NCBI TaxID: 1080348;
ModificationListOxidation; Acetyl; Carbamidomethyl
InstrumentLTQ Orbitrap Velos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-19 06:10:41ID requested
12020-01-09 11:05:56announced
22020-04-14 03:06:51announced2020-04-14: Updated publication reference for PubMed record(s): 32094587.
Publication List
Farhat DC, Swale C, Dard C, Cannella D, Ortet P, Barakat M, Sindikubwabo F, Belmudes L, De Bock PJ, Couté Y, Bougdour A, Hakimi MA, A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment. Nat Microbiol, 5(4):570-583(2020) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Toxoplasma gondii, TGME49_305340, co-immunoprecipitation, nanoLC-MS/MS
Contact List
Virginie Brun
contact affiliationEDyP
contact emailvirginie.brun@cea.fr
lab head
Yohann Cout��
contact affiliationEDyP
contact emailyohann.coute@cea.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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