PXD016814

PXD016814 is an original dataset announced via ProteomeXchange.

Title	Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease
Description	Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date, VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination with M. pneumoniae lipid-associated membrane proteins (LAMPs) induces lung lesions consistent with exacerbated disease following challenge, without reducing bacterial loads. Removal of lipid moieties from LAMPs prior to vaccination eliminates VED and reduces bacterial loads after infection. Collectively, these data indicate that lipid moieties of lipoproteins are the causative factors of M. pneumoniae VED.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:01:55.984.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jeremy Balsbaugh
SpeciesList	scientific name: Mycoplasma pneumoniae 19294; NCBI TaxID: 1213463;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-18 01:26:26	ID requested
1	2020-04-09 06:21:19	announced
2	2020-04-21 23:44:34	announced	2020-04-22: Updated publication reference for PubMed record(s): 32284882.
⏵ 3	2024-10-22 05:01:56	announced	2024-10-22: Updated project metadata.

10.1038/s41541-020-0181-x;

Mara AB, Gavitt TD, Tulman ER, Geary SJ, Szczepanek SM, lipoproteins are the causative factor of vaccine-enhanced disease. NPJ Vaccines, 5(1):31(2020) [pubmed]

submitter keyword: lipid associated membrane proteins, Q Exactive HF,mycoplasma pneumoniae

Jeremy Balsbaugh
contact affiliation	Director, UConn Proteomics & Metabolomics Facility, University of Connecticut, CT, USA
contact email	jeremy.balsbaugh@uconn.edu
lab head
Jeremy Balsbaugh
contact affiliation	University of Connecticut
contact email	jeremy.balsbaugh@uconn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD016814

PRIDE project URI

• PRIDE
  1. PXD016814
     1. Label: PRIDE project
     2. Name: Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease