PXD016814 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease |
Description | Vaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date, VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination with M. pneumoniae lipid-associated membrane proteins (LAMPs) induces lung lesions consistent with exacerbated disease following challenge, without reducing bacterial loads. Removal of lipid moieties from LAMPs prior to vaccination eliminates VED and reduces bacterial loads after infection. Collectively, these data indicate that lipid moieties of lipoproteins are the causative factors of M. pneumoniae VED. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:01:55.984.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jeremy Balsbaugh |
SpeciesList | scientific name: Mycoplasma pneumoniae 19294; NCBI TaxID: 1213463; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-12-18 01:26:26 | ID requested | |
1 | 2020-04-09 06:21:19 | announced | |
2 | 2020-04-21 23:44:34 | announced | 2020-04-22: Updated publication reference for PubMed record(s): 32284882. |
⏵ 3 | 2024-10-22 05:01:56 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41541-020-0181-x; |
Mara AB, Gavitt TD, Tulman ER, Geary SJ, Szczepanek SM, lipoproteins are the causative factor of vaccine-enhanced disease. NPJ Vaccines, 5(1):31(2020) [pubmed] |
Keyword List
submitter keyword: lipid associated membrane proteins, Q Exactive HF,mycoplasma pneumoniae |
Contact List
Jeremy Balsbaugh |
contact affiliation | Director, UConn Proteomics & Metabolomics Facility, University of Connecticut, CT, USA |
contact email | jeremy.balsbaugh@uconn.edu |
lab head | |
Jeremy Balsbaugh |
contact affiliation | University of Connecticut |
contact email | jeremy.balsbaugh@uconn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016814
- Label: PRIDE project
- Name: Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease