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PXD016814

PXD016814 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factors of vaccine-enhanced disease
DescriptionVaccine-enhanced disease (VED) occurs as a result of vaccination followed by infection with virulent Mycoplasma pneumoniae. To date, VED has prevented development of an efficacious vaccine against this significant human respiratory pathogen. Herein we report that vaccination with M. pneumoniae lipid-associated membrane proteins (LAMPs) induces lung lesions consistent with exacerbated disease following challenge, without reducing bacterial loads. Removal of lipid moieties from LAMPs prior to vaccination eliminates VED and reduces bacterial loads after infection. Collectively, these data indicate that lipid moieties of lipoproteins are the causative factors of M. pneumoniae VED.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:01:55.984.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJeremy Balsbaugh
SpeciesList scientific name: Mycoplasma pneumoniae 19294; NCBI TaxID: 1213463;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-18 01:26:26ID requested
12020-04-09 06:21:19announced
22020-04-21 23:44:34announced2020-04-22: Updated publication reference for PubMed record(s): 32284882.
32024-10-22 05:01:56announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41541-020-0181-x;
Mara AB, Gavitt TD, Tulman ER, Geary SJ, Szczepanek SM, lipoproteins are the causative factor of vaccine-enhanced disease. NPJ Vaccines, 5(1):31(2020) [pubmed]
Keyword List
submitter keyword: lipid associated membrane proteins, Q Exactive HF,mycoplasma pneumoniae
Contact List
Jeremy Balsbaugh
contact affiliationDirector, UConn Proteomics & Metabolomics Facility, University of Connecticut, CT, USA
contact emailjeremy.balsbaugh@uconn.edu
lab head
Jeremy Balsbaugh
contact affiliationUniversity of Connecticut
contact emailjeremy.balsbaugh@uconn.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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