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PXD016799

PXD016799 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePRMT1 inhibition induces differentiation of colon cancer cells
DescriptionColorectal cancer (CRC) is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women, with over 1.8 million new cases in 20181. Differentiation therapy has been recently revisited as a prospective approach in cancer therapy2 by targeting the aberrant growth, differentiation and cell death programs of cancer cells. Standard of care chemotherapy may eradicate cancer cells, but the aggressive cells can survive and resistance gradually develops. In contrast, differentiation therapy aims not to eradicate cancer bulk, but rather directs cancer cells towards inhibited proliferation and restoration of the apoptotic program, while maintaining a limited toxicity. Current data suggests that differentiation therapy can be an effective anti-cancer treatment approach, however discovery of the new differentiation inducing molecules with a higher therapeutic index is essential. We performed HTS screen for compounds mediating differentiation of colon cancer cell using a novel dual multiplex assay3. Here we show that PRMT type 1 inhibitor MS023 is a potent inducer of colon cancer cell differentiation with a large therapeutic window. Our findings has a great importance for following investigation and development of effective differentiation based anti CRC therapy applicable in the clinic.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:27:12.367.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMeital Kupervaser
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-17 04:14:39ID requested
12021-09-08 17:52:35announced
22024-10-22 05:27:17announced2024-10-22: Updated project metadata.
Publication List
Plotnikov A, Kozer N, Cohen G, Carvalho S, Duberstein S, Almog O, Solmesky LJ, Shurrush KA, Babaev I, Benjamin S, Gilad S, Kupervaser M, Levin Y, Gershovits M, Ben-Avraham D, Barr HM, PRMT1 inhibition induces differentiation of colon cancer cells. Sci Rep, 10(1):20030(2020) [pubmed]
10.1038/s41598-020-77028-8;
Keyword List
submitter keyword: MS023,PMRT1 inhibitors, colorectal cancer
Contact List
Barr Haim
contact affiliationWohl Institute for Drug Discovery, High Throughput Screening unit, Grand Israel National Center for Personalized Medicine, the Weizmann Institute of Science, Rehovot, Israel
contact emailhaim.barr@weizmann.ac.il
lab head
Meital Kupervaser
contact affiliationWeizmann Institute of Science
contact emailmeital.kupervaser@weizmann.ac.il
dataset submitter
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Dataset FTP location
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