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PXD016782

PXD016782 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDigestion of a variety of synthetic peptides by proteasomes
DescriptionProteasomes are large multi-subunit enzymes that act as the main producers of antigenic peptides presented at the cell surface to CD8+ T cells. They can simply cut proteins or recombine their fragments thereby generating novel sequences, i.e. spliced peptides via a process called proteasome-catalysed peptide splicing (PCPS). In order to gain more insight into these processes, we here perform in vitro digestions of 55 synthetic polypeptide substrates by proteasome isoforms followed by LC-MS/MS measurements using different Mass Spectrometers.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:01:57.606.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterArtem Mansurkhodzhaev
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; deamidated residue
InstrumentLTQ Orbitrap XL; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-16 23:50:34ID requested
12020-04-14 02:22:55announced
22020-06-30 04:41:51announced2020-06-30: Updated publication reference for PubMed record(s): 32415162.
32024-10-22 05:01:59announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41597-020-0487-6;
Specht G, Roetschke HP, Mansurkhodzhaev A, Henklein P, Textoris-Taube K, Urlaub H, Mishto M, Liepe J, Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes. Sci Data, 7(1):146(2020) [pubmed]
Keyword List
submitter keyword: Synthetic peptides, proteasome, digestion, LC-MS/MS
Contact List
Juliane Liepe
contact affiliationHead of research group Quantitative and Systems Biology; Max Planck Institute for Biophysical Chemistry; Goettingen;Germany
contact emailjuliane.liepe@mpibpc.mpg.de
lab head
Artem Mansurkhodzhaev
contact affiliationMax Planck Institute for Biophysical Chemistry
contact emailartem.mansurkhodzhaev@mpibpc.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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