PXD016771

PXD016771 is an original dataset announced via ProteomeXchange.

Title	L-Ascorbic acid and ��-Tocopherol synergistically triggers apoptosis inducing antileukemic effects of arsenic trioxide via oxidative stress in human acute promyelocytic leukemia cells.
Description	Chemosensitization is an effective strategy to overcome the drawbacks of arsenic trioxide (As2O3) treatment which may be possible through the use of dietary supplements in combination. Proteomic analysis revealed that the combination of arsenic trioxide with vitamins can alter a number of proteins related to the translation, cell cycle, oxidative stress and apoptotic pathways that adds to their effectiveness in the treatment of acute promyelocytic leukemia. This study provides the fact that HL-60 cells became more vulnerable to As2O3 in the presence of L-Ascorbic acid and ��-Tocopherol indicating that this combination may be a hopeful approach to increase the outcome of As2O3 in the treatment of acute promyelocytic leukemia.
HostingRepository	PRIDE
AnnounceDate	2020-01-10
AnnouncementXML	Submission_2020-01-10_06:47:21.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD016771
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MAHESH CHANDRAN V R
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Dehydrated; Oxidation; Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-16 03:27:23	ID requested
⏵ 1	2020-01-10 06:47:22	announced

Dataset with its publication pending

ProteomeXchange project tag: Cancer (B/D-HPP), Human Proteome Project

submitter keyword: human acute promyelocytic leukemia cells ,LC- MS/MS

dr.Abdul jaleel K A
contact affiliation	scientist EII , Rajiv Gandhi centre for Biotechnology
contact email	jaleel@rgcb.res.in
lab head
MAHESH CHANDRAN V R
contact affiliation	Technician
contact email	maheshchandran@rgcb.res.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016771
     1. Label: PRIDE project
     2. Name: L-Ascorbic acid and ��-Tocopherol synergistically triggers apoptosis inducing antileukemic effects of arsenic trioxide via oxidative stress in human acute promyelocytic leukemia cells.