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PXD016771

PXD016771 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleL-Ascorbic acid and ��-Tocopherol synergistically triggers apoptosis inducing antileukemic effects of arsenic trioxide via oxidative stress in human acute promyelocytic leukemia cells.
DescriptionChemosensitization is an effective strategy to overcome the drawbacks of arsenic trioxide (As2O3) treatment which may be possible through the use of dietary supplements in combination. Proteomic analysis revealed that the combination of arsenic trioxide with vitamins can alter a number of proteins related to the translation, cell cycle, oxidative stress and apoptotic pathways that adds to their effectiveness in the treatment of acute promyelocytic leukemia. This study provides the fact that HL-60 cells became more vulnerable to As2O3 in the presence of L-Ascorbic acid and ��-Tocopherol indicating that this combination may be a hopeful approach to increase the outcome of As2O3 in the treatment of acute promyelocytic leukemia.
HostingRepositoryPRIDE
AnnounceDate2020-01-10
AnnouncementXMLSubmission_2020-01-10_06:47:21.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD016771
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMAHESH CHANDRAN V R
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListAmmonia-loss; Dehydrated; Oxidation; Carbamidomethyl
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-16 03:27:23ID requested
12020-01-10 06:47:22announced
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Human Proteome Project
submitter keyword: human acute promyelocytic leukemia cells ,LC- MS/MS
Contact List
dr.Abdul jaleel K A
contact affiliationscientist EII , Rajiv Gandhi centre for Biotechnology
contact emailjaleel@rgcb.res.in
lab head
MAHESH CHANDRAN V R
contact affiliationTechnician
contact emailmaheshchandran@rgcb.res.in
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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