PXD016713

PXD016713 is an original dataset announced via ProteomeXchange.

Title	Chromatin bound O-GlcNAc proteins related to stress response and transcriptional regulation.
Description	O-GlcNAcylation performs a critical role in regulating stress response program and cellular homeostasis. However, systematic studies of O-GlcNAc regulated genotoxic stress-responsive transcriptional reprograming have been limited. The GalNAz metabolic labeled global chromatin-associated proteins were isolated from the cross-linked MCF-7 and MCF-7/ADR cells nucleus, and then modified by downstream click-chemistry. The de-crosslinked O-GlcNAz chromatin-bound proteins were enriched for label-free quantitative proteomics by LC-MS/MS.
HostingRepository	iProX
AnnounceDate	2020-08-30
AnnouncementXML	Submission_2023-03-01_19:26:02.512.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yubo liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-11 23:48:52	ID requested
1	2020-07-05 23:18:20	announced
⏵ 2	2023-03-01 19:26:03	announced	2023-03-02: Update publication information.

Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J, Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response. Nat Commun, 11(1):5898(2020) [pubmed]

submitter keyword: O-GlcNAc，metabolic labeling，proteomics

yubo liu
contact affiliation	Dalian University of Technology
contact email	liuyubo@dlut.edu.cn
lab head
yubo liu
contact affiliation	Dalian University of Technology
contact email	liuyubo@dlut.edu.cn
dataset submitter

iProX dataset URI