PXD016708

PXD016708 is an original dataset announced via ProteomeXchange.

Title	Native mass spectrometry of peptide-free and partially loaded MHC class I molecules
Description	A disulfide-stabilized MHC class I molecule (HLA-A*02:01(Y84C/A139C), short dsA2) was characterized by native mass spectrometry. dsA2 was shown to be structurally intact in absence of any peptide whereas its wild type form was not. Furthermore, it was observed that the mutation did not disrupt the binding of cognate peptides.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:13:25.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Janine-Denise Kopicki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q-Tof Ultima

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-11 07:42:47	ID requested
⏵ 1	2024-10-08 11:13:25	announced

10.1038/S41467-020-14862-4;

submitter keyword: peptide-binding, HLA-A, native MS,human, MHC class I

Charlotte Uetrecht
contact affiliation	Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Germany; European XFEL GmbH, Germany
contact email	charlotte.uetrecht@xfel.eu
lab head
Janine-Denise Kopicki
contact affiliation	CSSB Centre for Structural Systems Biology
contact email	janine.kopicki@leibniz-hpi.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD016708

PRIDE project URI

• PRIDE
  1. PXD016708
     1. Label: PRIDE project
     2. Name: Native mass spectrometry of peptide-free and partially loaded MHC class I molecules