PXD016707

PXD016707 is an original dataset announced via ProteomeXchange.

Title	In-depth proteomics and natural peptidomics analyses of human endometrial fluid
Description	Endometrial fluid reflects the status of the endometrium, being a good atraumatic source of information on embryo implantation and some pathological conditions. Although some attempts have been made to characterize it, the catalogue of the human endometrial fluid proteins remains incomplete and little has been done regarding the analysis of the containing natural peptides. In this work, we have thoroughly analyzed the protein and natural peptide content of endometrial fluid. Protein content coming from 11 different individuals was analyzed using the novel TIMS TOF Pro mass spectrometer. A total of 4694 proteins were identified with at least one peptide with FDR<1%, of which 2261 were identified in more than 50% of the samples. Besides, a pooled endometrial fluid sample was used for isolating the natural peptides and analyzed by mass spectrometry. Following this method we identified 3899 naturally-occurring peptides from 238 different proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:12:58.028.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro; Synapt MS; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-11 07:31:23	ID requested
1	2020-09-29 06:30:42	announced
⏵ 2	2024-10-22 05:12:58	announced	2024-10-22: Updated project metadata.

10.1016/j.jprot.2020.103652;

Azkargorta M, Breg, ó, n-Villahoz M, Escobes I, Ib, á, ñ, ez-P, é, rez J, Iloro I, Iglesias M, Diez-Zapirain M, Rabanal A, Prieto B, Moragues MD, Matorras R, Elortza F, In-depth proteomics and natural peptidomics analyses reveal antibacterial peptides in human endometrial fluid. J Proteomics, 216():103652(2020) [pubmed]

submitter keyword: natural peptidomics, timsTOF,Endometrial fluid

Felix Elortza
contact affiliation	Proteomics Platform, CIC bioGUNE, CIBERehd, ProteoRed-ISCIII, Bizkaia Science and Technology Park, Derio, Spain
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD016707

PRIDE project URI

• PRIDE
  1. PXD016707
     1. Label: PRIDE project
     2. Name: In-depth proteomics and natural peptidomics analyses of human endometrial fluid