PXD016690

PXD016690 is an original dataset announced via ProteomeXchange.

Title	Alteration of the plasma peptidome of gastrectomised patients during an OGTT
Description	Performing gastric bypass surgery on patients severely changes their gut hormone response to glucose. The plasma concentrations of Insulin and a number of associated incretin peptides are significantly raised shortly after ingestion of glucose. Typically the plasma concentrations of these peptides are monitored using immunoassays. A simple and high throughput plasma peptidomics approach was used to simulatneously monitor a large number of these peptides. Comparison of gastresctomised and control individuals showed significant increases of insulin, glucagon gene products, PYY and neurotensin.
HostingRepository	PRIDE
AnnounceDate	2020-06-05
AnnouncementXML	Submission_2020-06-04_22:26:35.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD016690
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Richard Kay
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Amidated; Oxidation; Acetyl; Carbamidomethyl; Gln->pyro-Glu
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-11 01:37:15	ID requested
⏵ 1	2020-06-04 22:26:36	announced

Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM, Mass spectrometric characterisation of the circulating peptidome following oral glucose ingestion in control and gastrectomised patients. Rapid Commun Mass Spectrom, 34(18):e8849(2020) [pubmed]

submitter keyword: Plasma, OGTT, peptidome, gut hormones

Fiona Gribble, Frank Reimann
contact affiliation	Wellcome Trust, MRC Institute of Metabolic Science, Cambridge University
contact email	fmg23@medschl.cam.ac.uk
lab head
Richard Kay
contact affiliation	University of Cambridge
contact email	rgk27@medschl.cam.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016690
     1. Label: PRIDE project
     2. Name: Alteration of the plasma peptidome of gastrectomised patients during an OGTT