⮝ Full datasets listing

PXD016665

PXD016665 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSHANK2A and SHANK2A(R841X) mouse brain SWATH quantitative proteomics
DescriptionThe high molecular complexity of the SHANK scaffold and its fundamental role in neural circuitries governing social behavior is not well understood. Here we analyzed two newly generated transgenic mouse lines with the SHANK2A wild-type isoform and the other with SHANK2A carrying a SHANK2A(R841X) point mutation. The proteome of hippocampal synapse-enriched fraction for both lines was investigated by quantitative SWATH proteomic analysis in order to identify synaptic proteins and signaling pathways that respond to the SHANK2 isoforms.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:33:41.580.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMiguel A. Gonzalez-Lozano
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListL-cysteine methyl disulfide
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-09 06:47:48ID requested
12022-02-23 10:31:00announced
22023-11-14 08:50:29announced2023-11-14: Updated project metadata.
32024-10-22 05:33:42announced2024-10-22: Updated project metadata.
Publication List
10.1038/S41380-021-01140-Y;
Keyword List
submitter keyword: LC-MSMS,SHANK2A, Brain, SWATH, Hippocampus, Mouse
Contact List
Ka Wan Li
contact affiliationDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands
contact emailk.w.li@vu.nl
lab head
Miguel A. Gonzalez-Lozano
contact affiliationDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam
contact emailm.a.gonzalezlozano@vu.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD016665
PRIDE project URI
Repository Record List
[ + ]