PXD016665

PXD016665 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SHANK2A and SHANK2A(R841X) mouse brain SWATH quantitative proteomics
Description	The high molecular complexity of the SHANK scaffold and its fundamental role in neural circuitries governing social behavior is not well understood. Here we analyzed two newly generated transgenic mouse lines with the SHANK2A wild-type isoform and the other with SHANK2A carrying a SHANK2A(R841X) point mutation. The proteome of hippocampal synapse-enriched fraction for both lines was investigated by quantitative SWATH proteomic analysis in order to identify synaptic proteins and signaling pathways that respond to the SHANK2 isoforms.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:33:41.580.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Miguel A. Gonzalez-Lozano
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	L-cysteine methyl disulfide
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-09 06:47:48	ID requested
1	2022-02-23 10:31:00	announced
2	2023-11-14 08:50:29	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:33:42	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/S41380-021-01140-Y;

10.1038/S41380-021-01140-Y;

Keyword List

submitter keyword: LC-MSMS,SHANK2A, Brain, SWATH, Hippocampus, Mouse

submitter keyword: LC-MSMS,SHANK2A, Brain, SWATH, Hippocampus, Mouse

Contact List

Ka Wan Li
contact affiliation	Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands
contact email	k.w.li@vu.nl
lab head
Miguel A. Gonzalez-Lozano
contact affiliation	Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam
contact email	m.a.gonzalezlozano@vu.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD016665
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD016665

PRIDE project URI

Repository Record List

[ + ]