PXD016665 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SHANK2A and SHANK2A(R841X) mouse brain SWATH quantitative proteomics |
Description | The high molecular complexity of the SHANK scaffold and its fundamental role in neural circuitries governing social behavior is not well understood. Here we analyzed two newly generated transgenic mouse lines with the SHANK2A wild-type isoform and the other with SHANK2A carrying a SHANK2A(R841X) point mutation. The proteome of hippocampal synapse-enriched fraction for both lines was investigated by quantitative SWATH proteomic analysis in order to identify synaptic proteins and signaling pathways that respond to the SHANK2 isoforms. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:33:41.580.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Miguel A. Gonzalez-Lozano |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | L-cysteine methyl disulfide |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-12-09 06:47:48 | ID requested | |
1 | 2022-02-23 10:31:00 | announced | |
2 | 2023-11-14 08:50:29 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:33:42 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: LC-MSMS,SHANK2A, Brain, SWATH, Hippocampus, Mouse |
Contact List
Ka Wan Li |
contact affiliation | Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands |
contact email | k.w.li@vu.nl |
lab head | |
Miguel A. Gonzalez-Lozano |
contact affiliation | Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam |
contact email | m.a.gonzalezlozano@vu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD016665 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016665
- Label: PRIDE project
- Name: SHANK2A and SHANK2A(R841X) mouse brain SWATH quantitative proteomics