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PXD016579

PXD016579 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
Description131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled by analysis of gene copy number variation, whole exome sequence, methylome, transcriptome, proteome, and phospho(Tyr)-proteome. Proteome profiling resolved the known major histology subtypes and revealed 3 proteome subtypes (proteotypes) among adenocarcinoma and 2 in squamous cell carcinoma that were associated with distinct protein-phosphotyrosine signatures and patient survival. Proteomes of human tumor were discernible from murine stroma. Stromal proteomes were similar between histological subtypes, but two adenocarcinoma proteotypes had distinct stromal proteomes. Tumor and stromal proteotypes comprise signatures of targetable biological pathways suggesting that patient stratification by proteome profiling may be an actionable approach to precisely diagnose and treat cancer.
HostingRepositoryPRIDE
AnnounceDate2021-11-24
AnnouncementXMLSubmission_2021-11-24_12:02:43.615.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShideh Mirhadi
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-04 03:33:08ID requested
12021-11-24 12:02:44announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: NSCLC, PDX, Lung, TMT
Contact List
Michael F. Moran
contact affiliationMolecular Genetics, University of Toronto Hospital for Sick Children, Toronto, Canada
contact emailm.moran@utoronto.ca
lab head
Shideh Mirhadi
contact affiliationHospital for Sick Children
contact emailshideh.mirhadi@sickkids.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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