PXD016560

PXD016560 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Signature of Nucleus Pulposus of Human Intervertebral Disc
Description	Intervertebral Disc (IVD) degeneration leading to Low back pain (LBP) is the most common musculoskeletal disorder. Lack of knowledge on the intricate homeostatic mechanisms necessitates proteomic characterisation of a normal human IVD to understand the biological process and unravel the pathomechanisms of degenerative disc disease (DDD). In this study, we employed proteomic approach coupled with tandem mass-spectrometry to derive the comprehensive list of proteins expressed in true biologically normal control discs. This would serve as the basis for identifying the interacting molecules participating in significant biological processes and pathways disrupted during aging and degeneration.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-08_17:26:10.644.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD016560
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chitraa Tangavel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-04 01:36:25	ID requested
⏵ 1	2021-09-08 17:26:11	announced

Publication List

Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D, Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma. Neurospine, 17(2):426-442(2020) [pubmed]

Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D, Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma. Neurospine, 17(2):426-442(2020) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: ESI-LC-MS/MS, Human, IVD, NP

curator keyword: Biomedical

submitter keyword: ESI-LC-MS/MS, Human, IVD, NP

Contact List

Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopaedic Research and Education Foundation, 187, Mettupalayam road, Kavundampalayam, Coimbatore-641030 Tamil Nadu, India.
contact email	cthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016560
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016560

PRIDE project URI

Repository Record List

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