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PXD016560

PXD016560 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Signature of Nucleus Pulposus of Human Intervertebral Disc
DescriptionIntervertebral Disc (IVD) degeneration leading to Low back pain (LBP) is the most common musculoskeletal disorder. Lack of knowledge on the intricate homeostatic mechanisms necessitates proteomic characterisation of a normal human IVD to understand the biological process and unravel the pathomechanisms of degenerative disc disease (DDD). In this study, we employed proteomic approach coupled with tandem mass-spectrometry to derive the comprehensive list of proteins expressed in true biologically normal control discs. This would serve as the basis for identifying the interacting molecules participating in significant biological processes and pathways disrupted during aging and degeneration.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-08_17:26:10.644.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD016560
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterChitraa Tangavel
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListCarbamidomethyl
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-04 01:36:25ID requested
12021-09-08 17:26:11announced
Publication List
Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D, Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma. Neurospine, 17(2):426-442(2020) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: ESI-LC-MS/MS, Human, IVD, NP
Contact List
Chitraa Tangavel
contact affiliationResearch Scientist, Ganga Orthopaedic Research and Education Foundation, 187, Mettupalayam road, Kavundampalayam, Coimbatore-641030 Tamil Nadu, India.
contact emailcthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliationResearch Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact emailcthangavel@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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