PXD016560 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Signature of Nucleus Pulposus of Human Intervertebral Disc |
Description | Intervertebral Disc (IVD) degeneration leading to Low back pain (LBP) is the most common musculoskeletal disorder. Lack of knowledge on the intricate homeostatic mechanisms necessitates proteomic characterisation of a normal human IVD to understand the biological process and unravel the pathomechanisms of degenerative disc disease (DDD). In this study, we employed proteomic approach coupled with tandem mass-spectrometry to derive the comprehensive list of proteins expressed in true biologically normal control discs. This would serve as the basis for identifying the interacting molecules participating in significant biological processes and pathways disrupted during aging and degeneration. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-08_17:26:10.644.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD016560 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Chitraa Tangavel |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Carbamidomethyl |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-12-04 01:36:25 | ID requested | |
⏵ 1 | 2021-09-08 17:26:11 | announced | |
Publication List
Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D, Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma. Neurospine, 17(2):426-442(2020) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: ESI-LC-MS/MS, Human, IVD, NP |
Contact List
Chitraa Tangavel |
contact affiliation | Research Scientist, Ganga Orthopaedic Research and Education Foundation, 187, Mettupalayam road, Kavundampalayam, Coimbatore-641030 Tamil Nadu, India. |
contact email | cthangavel@gmail.com |
lab head | |
Chitraa Tangavel |
contact affiliation | Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India |
contact email | cthangavel@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016560 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016560
- Label: PRIDE project
- Name: Proteomic Signature of Nucleus Pulposus of Human Intervertebral Disc