PXD016547

PXD016547 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphoproteome analysis of pediatric acute leukemia patients and matched xenografts
Description	Proteomics reveal PTM stability after xenotransplantation in murine models. Phosphopeptides enriched using magnetic FeNTA beads were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisition (DDA) mass spectrometry analysis. Spectral information from DDA and DIA data were used to generate a sample-specific library for targeted analysis to identify and quantify proteins. We present phosphorylation profiles for paired patients and patient-derived xenografts, pediatric leukemic cell lines, and normal individuals.
HostingRepository	MassIVE
AnnounceDate	2022-08-24
AnnouncementXML	Submission_2022-08-24_14:48:36.577.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Philipp Lange
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Phospho; Acetyl; Oxidation; Carbamidomethyl
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-02 16:06:42	ID requested
⏵ 1	2022-08-24 14:48:37	announced

Publication List

Uzozie AC, Ergin EK, Rolf N, Tsui J, Lorentzian A, Weng SSH, Nierves L, Smith TG, Lim CJ, Maxwell CA, Reid GSD, Lange PF, PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways. J Exp Clin Cancer Res, 40(1):96(2021) [pubmed]

Uzozie AC, Ergin EK, Rolf N, Tsui J, Lorentzian A, Weng SSH, Nierves L, Smith TG, Lim CJ, Maxwell CA, Reid GSD, Lange PF, PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways. J Exp Clin Cancer Res, 40(1):96(2021) [pubmed]

Keyword List

submitter keyword: leukemia, N terminome, phosphorylation, proteome, xenograft

submitter keyword: leukemia, N terminome, phosphorylation, proteome, xenograft

Contact List

Dr. Philipp Lange
contact affiliation	The University of British Columbia
contact email	philipp.lange@ubc.ca
lab head
Philipp Lange
contact affiliation	UBC
contact email	philipp.lange@ubc.ca
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084645/