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PXD016545

PXD016545 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleN terminome analysis of pediatric acute leukemia patients and matched xenografts
DescriptionProteomics reveal PTM stability after xenotransplantation in murine models. N termini enriched using HUNTER technique were analyzed by Data Independent Acquisition (DIA) mass spectrometry. High-pH fractionation was performed on a pool of samples, followed by data dependent acquisition (DDA) mass spectrometry analysis. Spectral information from DDA and DIA data were used to generate a sample-specific library for targeted analysis to identify and quantify proteins. We present a global landscape of proteolytic processing in paired patients and patient-derived xenografts, pediatric leukemic cell lines, and normal individuals.
HostingRepositoryMassIVE
AnnounceDate2022-08-24
AnnouncementXMLSubmission_2022-08-24_14:48:44.181.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPhilipp Lange
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListAcetyl; Oxidation; Carbamidomethyl; Dimethyl; Glu->pyro-Glu; Gln->pyro-Glu
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-02 14:02:37ID requested
12022-08-24 14:48:44announced
Publication List
Uzozie AC, Ergin EK, Rolf N, Tsui J, Lorentzian A, Weng SSH, Nierves L, Smith TG, Lim CJ, Maxwell CA, Reid GSD, Lange PF, PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways. J Exp Clin Cancer Res, 40(1):96(2021) [pubmed]
Keyword List
submitter keyword: leukemia, N terminome, phosphorylation, proteome, xenograft
Contact List
Dr. Philipp Lange
contact affiliationThe University of British Columbia
contact emailphilipp.lange@ubc.ca
lab head
Philipp Lange
contact affiliationUBC
contact emailphilipp.lange@ubc.ca
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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