PXD016521

PXD016521 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of ∆4-CYB complex III mutant cybrids
Description	The mitochondrial respiratory chain (MRC) enzymes associate in supercomplexes (SC). This structural interdependency may explain why defects in a single component often produce combined enzyme deficiencies in patients. A point in case is the alleged destabilization of complex I in the absence of complex III. To clarify the structural and functional relationships between complexes, we have used comprehensive proteomic, functional and biogenetical approaches to analyze a MT-CYB-deficient human cell line.
HostingRepository	PRIDE
AnnounceDate	2020-01-07
AnnouncementXML	Submission_2020-01-07_10:55:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Erika Fernandez-Vizarra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-29 02:37:53	ID requested
⏵ 1	2020-01-07 10:55:05	announced

Dataset with its publication pending

submitter keyword: Human, Mitochondria

Massimo Zeviani
contact affiliation	Medical Research Council-Mitochondrial Biology Unit. University of Cambridge, UK.
contact email	mdz21@mrc-mbu.cam.ac.uk
lab head
Erika Fernandez-Vizarra
contact affiliation	MRC-Mitochondrial Biology Unit
contact email	emfvb2@mrc-mbu.cam.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD016521

PRIDE project URI

• PRIDE
  1. PXD016521
     1. Label: PRIDE project
     2. Name: Proteomic analysis of ∆4-CYB complex III mutant cybrids