PXD016493 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | MEK and PI3K resistant proteome of pancreatic cancer cells |
Description | MEK and PI3K inhibition on pancreatic cancer cells has demonstrated the existence of intrinsic resistance. Therefore, a comprehensive proteome profiling is needed to understand the associated molecular phenotype. PANC-1 and MIA PaCa-2 cancer cells were studied by label-free data-independent acquisition (SWATH) mass spectrometry with extensive peptide fractionation to quantitate and reveal differential expression of several proteins between resistant and sensitive cells. Proteomic differences cover a broad scope of molecular processes and putative candidate proteins for drug response. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-10 |
AnnouncementXML | Submission_2025-03-10_14:55:28.231.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Juan Francisco Martinez-Aguilar |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-28 02:42:37 | ID requested | |
⏵ 1 | 2025-03-10 14:55:28 | announced | |
Publication List
Keyword List
submitter keyword: MEK, proteomics, PI3K, pancreatic cancer |
Contact List
Juan Francisco |
contact affiliation | National Autonomous University of Mexico. Mexico City |
contact email | jmartinez@cic.unam.mx |
lab head | |
Juan Francisco Martinez-Aguilar |
contact affiliation | Universidad Nacional Autonoma de Mexico |
contact email | jmartinez@cic.unam.mx |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016493
- Label: PRIDE project
- Name: MEK and PI3K resistant proteome of pancreatic cancer cells