PXD016493

PXD016493 is an original dataset announced via ProteomeXchange.

Title	MEK and PI3K resistant proteome of pancreatic cancer cells
Description	MEK and PI3K inhibition on pancreatic cancer cells has demonstrated the existence of intrinsic resistance. Therefore, a comprehensive proteome profiling is needed to understand the associated molecular phenotype. PANC-1 and MIA PaCa-2 cancer cells were studied by label-free data-independent acquisition (SWATH) mass spectrometry with extensive peptide fractionation to quantitate and reveal differential expression of several proteins between resistant and sensitive cells. Proteomic differences cover a broad scope of molecular processes and putative candidate proteins for drug response.
HostingRepository	PRIDE
AnnounceDate	2025-03-10
AnnouncementXML	Submission_2025-03-10_14:55:28.231.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Francisco Martinez-Aguilar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-28 02:42:37	ID requested
⏵ 1	2025-03-10 14:55:28	announced

10.1016/J.BBRC.2021.03.018;

submitter keyword: MEK, proteomics, PI3K, pancreatic cancer

Juan Francisco
contact affiliation	National Autonomous University of Mexico. Mexico City
contact email	jmartinez@cic.unam.mx
lab head
Juan Francisco Martinez-Aguilar
contact affiliation	Universidad Nacional Autonoma de Mexico
contact email	jmartinez@cic.unam.mx
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD016493

PRIDE project URI

• PRIDE
  1. PXD016493
     1. Label: PRIDE project
     2. Name: MEK and PI3K resistant proteome of pancreatic cancer cells