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PXD016488

PXD016488 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Profiling of Retinoblastoma-Derived Exosomes reveals potential biomarkers of vitreous seeding
DescriptionRetinoblastoma (RB) is the most common tumor of the eye in early childhood. Despite recent advances in conservative treatment have greatly improved the visual outcome, local tumor control remain difficult in presence of massive vitreous seeding. Traditional biopsy has long been considered unsafe in RB, due to the risk of extraocular spread. Thus, the identification of new biomarkers is crucial to design safer diagnostic and more effective therapeutic approaches. Exosomes represent an interesting alternative to detect tumor-associated biomarkers. In this study we defined the protein signature of exosomes released by RB tumors (RBT) and vitreous seeding (RBVS) primary cell lines by high resolution mass spectrometry. A total of 5666 proteins were identified. Among these, 5223 and 3637 were expressed in exosome RBT and one RBVS group respectively.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:27:04.830.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrea Petretto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-11-28 02:42:14ID requested
12021-09-08 17:10:19announced
22024-10-22 05:27:05announced2024-10-22: Updated project metadata.
Publication List
Galardi A, Colletti M, Lavarello C, Di Paolo V, Mascio P, Russo I, Cozza R, Romanzo A, Valente P, De Vito R, Pascucci L, Peinado H, Carcaboso AM, Petretto A, Locatelli F, Di Giannatale A, Proteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding. Cancers (Basel), 12(6):(2020) [pubmed]
10.3390/cancers12061555;
Keyword List
submitter keyword: exosomes, proteomics,Retinoblastoma, biomarkers
Contact List
Andrea Petretto
contact affiliationIst. G. Gaslini
contact emaila.petretto@gmail.com
lab head
Andrea Petretto
contact affiliationGaslini Children's Hospital
contact emaila.petretto@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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