PXD016455

PXD016455 is an original dataset announced via ProteomeXchange.

Title	Protein complexes between PGRMC1 and actin-associated proteins are disrupted by AG-205
Description	PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in regulating membrane trafficking and in cancer progression and response to therapies. To further understand the functions of PGRMC1 and the mechanism of the small molecule inhibitor of PGRMC1, AG-205, proteins differentially bound to PGRMC1 were identified following AG-205 treatment of MIA PaCa-2 cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:50:22.604.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-27 00:52:15	ID requested
1	2020-01-24 00:21:41	announced
2	2020-01-24 03:25:28	announced	2020-01-24: Updated publication reference for DOI(s): 10.1016/j.bbrc.2019.12.108.
3	2020-01-29 05:47:55	announced	2020-01-24: Updated publication reference for DOI(s): 10.1016/j.bbrc.2019.12.108. 2020-01-29: Updated publication reference for PubMed record(s): 31980178. 2020-01-29: Updated publication reference for DOI(s): 10.1016/j.bbrc.2019.12.108.
4	2020-02-17 03:22:09	announced	2020-01-24: Updated publication reference for DOI(s): 10.1016/j.bbrc.2019.12.108. 2020-01-29: Updated publication reference for PubMed record(s): 31980178. 2020-01-29: Updated publication reference for DOI(s): 10.1016/j.bbrc.2019.12.108. 2020-02-17: Updat
⏵ 5	2023-11-14 08:50:23	announced	2023-11-14: Updated project metadata.

Teakel SL, Ludescher M, Thejer BM, Poschmann G, Forwood JK, Neubauer H, Cahill MA, Protein complexes including PGRMC1 and actin-associated proteins are disrupted by AG-205. Biochem Biophys Res Commun, 524(1):64-69(2020) [pubmed]

curator keyword: Biological

submitter keyword: AP-MS, cancer,PGRMC1, trafficking

Gereon Poschmann
contact affiliation	Heinrich Heine University Düsseldorf Molecular Medicine
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD016455

PRIDE project URI

• PRIDE
  1. PXD016455
     1. Label: PRIDE project
     2. Name: Protein complexes between PGRMC1 and actin-associated proteins are disrupted by AG-205