PXD016452
PXD016452 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species |
| Description | Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of membrane proteins upon L. monocytogenes infection in dendritic cells. We showed that Dynein light chain 1 (Dynll1) formed a persistent complex with the mitochondrial cytochrome oxidase, Cox4i1 that is disturbed by pathogen insult. We discovered that the dissociation of the Dynll1-Cox4i1 complex is required for the release of mitochondrial reactive oxygen species and serves as a regulator of intracellular proliferation of Listeria monocytogenes. Our study shows that Dynll1 is an inhibitor of mitochondrial reactive oxygen species and can serve as a potential molecular drug target for antibacterial treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2020-02-17 |
| AnnouncementXML | Submission_2020-06-24_03:26:54.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiangbei Yuan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-11-26 21:24:09 | ID requested | |
| 1 | 2020-02-17 03:59:54 | announced | |
| ⏵ 2 | 2020-06-24 03:26:55 | announced | 2020-06-24: Update publication information. |
Publication List
| Yuan J, Zheng Z, Wang L, Ran H, Tang X, Xie X, Li F, Liu F, Wang X, Zhang J, Zhang J, Huang Y, Xia X, Wan Y, The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species. Infect Immun, 88(4):(2020) [pubmed] |
Keyword List
| submitter keyword: Dynll1-Cox4il Complex Listeria monocytogenes Reactive oxygen species Membrane proteins |
Contact List
| Ying Wan | |
|---|---|
| contact affiliation | Chongqing University and Army Medical University |
| contact email | Wanying516@foxmail.com |
| lab head | |
| Jiangbei Yuan | |
| contact affiliation | Chongqing University |
| contact email | Yuanjiangbei@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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