PXD016440

PXD016440 is an original dataset announced via ProteomeXchange.

Title	Time-resolved extracellular matrix atlas of the developing human skin dermis
Description	Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of dermal matrix from birth to aging remain unclear. Furthermore, it is not understood how the ECM microenvironment supports the functions of skin development across different age groups. We used a decellularization method and matrisome analysis to compare the composition, expression, and function of the dermal ECM in neonate, teenage, adult, and elderly skin. We found that the collagens, glycoproteins, proteoglycans, and regulatory factors that support skin development and function together with these core ECM proteins were differentially expressed at different ages. We also identified ECM expression markers during the process of skin development. Our results systematically revealed the characteristics of ECM synthesis, response to growth factors, water conservation, anti-oxidation, and the ability of the ECM to support epidermal stem cell growth via the basement membrane in young skin, as well as the characteristics of response to wound repair and fungal invasion in aging skin.
HostingRepository	iProX
AnnounceDate	2022-11-28
AnnouncementXML	Submission_2022-11-27_21:41:53.568.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Leng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-25 18:00:19	ID requested
⏵ 1	2022-11-27 21:41:54	announced

Li M, Li X, Liu B, Lv L, Wang W, Gao D, Zhang Q, Jiang J, Chai M, Yun Z, Tan Y, Gong F, Wu Z, Zhu Y, Ma J, Leng L, Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis. Front Cell Dev Biol, 9():783456(2021) [pubmed]

submitter keyword: decellularization, extracellular matrix, matrisome, skin development, skin aging

Ling Leng
contact affiliation	Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.
contact email	zhenlinger@126.com
lab head
Ling Leng
contact affiliation	Department of Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.
contact email	zhenlinger@126.com
dataset submitter

iProX dataset URI