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PXD016384

PXD016384 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAcetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase
DescriptionAcetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of two bacterial mutants lacking putative lysine deacetylases encoded by genes BP0960 and BP3063 and compared them with the acetylome of wild-type B. pertussis. The results suggest that acetylation on lysine residues may modulate the activities of proteins involved in bacterial virulence and of multiple histone-like proteins.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:09:27.034.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIvo Fabrik
SpeciesList scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251); NCBI TaxID: 257313;
ModificationListN6-acetyl-L-lysine; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-11-21 06:51:11ID requested
12020-07-18 18:32:46announced
22024-10-22 05:09:31announced2024-10-22: Updated project metadata.
Publication List
10.1021/acs.jproteome.0c00178;
Novak J, Fabrik I, Jurnecka D, Holubova J, Stanek O, Sebo P, Acetylome is Shaped by Lysine Deacetylase Bkd1. J Proteome Res, 19(9):3680-3696(2020) [pubmed]
Keyword List
submitter keyword: Acetylome,Bordetella pertussis, Deacetylase activity
Contact List
Prof. Peter Sebo, PhD.
contact affiliationLaboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
contact emailsebo@biomed.cas.cz
lab head
Ivo Fabrik
contact affiliationBiomedical Research Center, University Hospital Hradec Kralove
contact emailivo.fabrik@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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