PXD016384 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Acetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase |
Description | Acetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of two bacterial mutants lacking putative lysine deacetylases encoded by genes BP0960 and BP3063 and compared them with the acetylome of wild-type B. pertussis. The results suggest that acetylation on lysine residues may modulate the activities of proteins involved in bacterial virulence and of multiple histone-like proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:09:27.034.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ivo Fabrik |
SpeciesList | scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251); NCBI TaxID: 257313; |
ModificationList | N6-acetyl-L-lysine; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-21 06:51:11 | ID requested | |
1 | 2020-07-18 18:32:46 | announced | |
⏵ 2 | 2024-10-22 05:09:31 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1021/acs.jproteome.0c00178; |
Novak J, Fabrik I, Jurnecka D, Holubova J, Stanek O, Sebo P, Acetylome is Shaped by Lysine Deacetylase Bkd1. J Proteome Res, 19(9):3680-3696(2020) [pubmed] |
Keyword List
submitter keyword: Acetylome,Bordetella pertussis, Deacetylase activity |
Contact List
Prof. Peter Sebo, PhD. |
contact affiliation | Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic |
contact email | sebo@biomed.cas.cz |
lab head | |
Ivo Fabrik |
contact affiliation | Biomedical Research Center, University Hospital Hradec Kralove |
contact email | ivo.fabrik@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016384
- Label: PRIDE project
- Name: Acetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase