PXD016172

PXD016172 is an original dataset announced via ProteomeXchange.

Title	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
Description	Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/β-catenin pathway, which plays critical roles in CRC pathogenesis. Here we have identified a β-catenin-independent function of BCL9 in a poor-prognosis subtype of CRC tumors characterized by expression of stromal and neural associated genes. In response to spontaneous calcium transients or cellular stress, BCL9 is recruited adjacent to the interchromosomal regions, where it stabilizes the mRNA of calcium signaling and neural associated genes by interacting with paraspeckle proteins. BCL9 subsequently promotes tumor progression and remodeling of the tumor microenvironment (TME) by sustaining the calcium transients and neurotransmitter-dependent communication among CRC cells. These data provide additional insights into the role of BCL9 in tumor pathogenesis and point towards additional avenues for therapeutic intervention.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_15:13:42.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD016172
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Meng Jiang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Methyl; Oxidation; Carbamidomethyl
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-06 02:56:21	ID requested
⏵ 1	2020-05-26 15:13:43	announced

Jiang M, Kang Y, Sewastianik T, Wang J, Tanton H, Alder K, Dennis P, Xin Y, Wang Z, Liu R, Zhang M, Huang Y, Loda M, Srivastava A, Chen R, Liu M, Carrasco RD, BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins. Nat Commun, 11(1):19(2020) [pubmed]

submitter keyword: BCL9, colorectal cancer, paraspeckles

Meng Jiang
contact affiliation	Harbin medical university
contact email	mengjiang@hrbmu.edu.cn
lab head
Meng Jiang
contact affiliation	Harbin Medical University
contact email	mengjiang@hrbmu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016172
     1. Label: PRIDE project
     2. Name: BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins