PXD016112 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Immunopeptidome analysis of 4T1 murine breast cancer cells. |
Description | This study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC peptides thus identified, an Endogenous Retroviral (ERV) peptide was also found, and this peptide, as well as several other peptides from TAAs, were shown to possess tumor control potential in a cancer vaccine setting in mice, by restricting tumor growth compared to controls. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-17 |
AnnouncementXML | Submission_2022-02-16_23:54:09.144.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rui Branca |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue; monohydroxylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-11-01 07:38:35 | ID requested | |
⏵ 1 | 2022-02-16 23:54:10 | announced | |
Publication List
Peltonen K, Feola S, Umer HM, Chiaro J, Mermelekas G, Yl, ö, sm, ä, ki E, Pesonen S, Branca RMM, Lehti, ö J, Cerullo V, Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy. Cancers (Basel), 13(14):(2021) [pubmed] |
Keyword List
submitter keyword: Orbitrap Fusion, immunopeptidome, ligandome, murine, mouse, 4T1, cancer, MHC-I |
Contact List
Janne Lehtiö |
contact affiliation | Oncology-Pathology, Scilifelab, Karolinska Institutet, Stockholm, Sweden |
contact email | janne.lehtio@ki.se |
lab head | |
Rui Branca |
contact affiliation | Clinical Proteomics Unit, Dep. of Oncology-Pathology |
contact email | rui.mamede-branca@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016112 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016112
- Label: PRIDE project
- Name: Immunopeptidome analysis of 4T1 murine breast cancer cells.