PXD016112

PXD016112 is an original dataset announced via ProteomeXchange.

Title	Immunopeptidome analysis of 4T1 murine breast cancer cells.
Description	This study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC peptides thus identified, an Endogenous Retroviral (ERV) peptide was also found, and this peptide, as well as several other peptides from TAAs, were shown to possess tumor control potential in a cancer vaccine setting in mice, by restricting tumor growth compared to controls.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-16_23:54:09.144.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Branca
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-11-01 07:38:35	ID requested
⏵ 1	2022-02-16 23:54:10	announced

Peltonen K, Feola S, Umer HM, Chiaro J, Mermelekas G, Yl, ö, sm, ä, ki E, Pesonen S, Branca RMM, Lehti, ö J, Cerullo V, Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy. Cancers (Basel), 13(14):(2021) [pubmed]

submitter keyword: Orbitrap Fusion, immunopeptidome, ligandome, murine, mouse, 4T1, cancer, MHC-I

Janne Lehtiö
contact affiliation	Oncology-Pathology, Scilifelab, Karolinska Institutet, Stockholm, Sweden
contact email	janne.lehtio@ki.se
lab head
Rui Branca
contact affiliation	Clinical Proteomics Unit, Dep. of Oncology-Pathology
contact email	rui.mamede-branca@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD016112

PRIDE project URI

• PRIDE
  1. PXD016112
     1. Label: PRIDE project
     2. Name: Immunopeptidome analysis of 4T1 murine breast cancer cells.