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PXD016112

PXD016112 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmunopeptidome analysis of 4T1 murine breast cancer cells.
DescriptionThis study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC peptides thus identified, an Endogenous Retroviral (ERV) peptide was also found, and this peptide, as well as several other peptides from TAAs, were shown to possess tumor control potential in a cancer vaccine setting in mice, by restricting tumor growth compared to controls.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-16_23:54:09.144.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRui Branca
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; monohydroxylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-11-01 07:38:35ID requested
12022-02-16 23:54:10announced
Publication List
Peltonen K, Feola S, Umer HM, Chiaro J, Mermelekas G, Yl, ö, sm, ä, ki E, Pesonen S, Branca RMM, Lehti, ö J, Cerullo V, Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy. Cancers (Basel), 13(14):(2021) [pubmed]
Keyword List
submitter keyword: Orbitrap Fusion, immunopeptidome, ligandome, murine, mouse, 4T1, cancer, MHC-I
Contact List
Janne Lehtiö
contact affiliationOncology-Pathology, Scilifelab, Karolinska Institutet, Stockholm, Sweden
contact emailjanne.lehtio@ki.se
lab head
Rui Branca
contact affiliationClinical Proteomics Unit, Dep. of Oncology-Pathology
contact emailrui.mamede-branca@ki.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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