PXD016096

PXD016096 is an original dataset announced via ProteomeXchange.

Title	A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort
Description	Testosterone deficiency afflicts approximately 30% of men aged from 40-89 years. It is associated with type 2 diabetes, metabolic syndrome and cardiovascular disease. However, the causality of the relationship between low testosterone and metabolic diseases is unclear. We have analysed plasma samples from thirty healthy male volunteers (19-32 years of age) with pharmacologically-induced testosterone deficiency. Blood samples were collected under three conditions: normal testosterone (baseline), ‘zero’ testosterone and ‘restored’ testosterone. As a proof-of-concept, a sample pooling approach was used to obtain one pool per condition, with each pool consisting of 30 individual samples. The proteomic profiles identified significant functional differences, related to the innate immune system, the regulation of insuline-like growth factors, collagen degradation, glycolysis/gluconeogenesis process, among others.
HostingRepository	PRIDE
AnnounceDate	2020-08-03
AnnouncementXML	Submission_2020-08-02_22:30:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aniel Sanchez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-31 04:37:38	ID requested
⏵ 1	2020-08-02 22:30:14	announced

Pla I, Sahlin KB, Paw, ł, owski K, Appelqvist R, Marko-Varga G, Sanchez A, Malm J, A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort. J Proteomics, 220():103768(2020) [pubmed]

submitter keyword: Testosterone, proteomcis, mass spectrometry

Johan Malm
contact affiliation	Department of translation medicine.
contact email	johan.malm@med.lu.se
lab head
Aniel Sanchez
contact affiliation	Lund University
contact email	aniel.sanchez@med.lu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD016096
     1. Label: PRIDE project
     2. Name: A pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort