PXD016086 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Thermal proteome profiling in of CA-074me |
Description | We performed thermal proteome profiling (TPP) to study changes to protein thermal stability and abundance of CA-074me (cathepsin inhibitor) in RAW264.7 macrophages after Salmonella typhimurium infection. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:58:13.336.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andre Mateus |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); NCBI TaxID: 99287; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-10-31 01:20:59 | ID requested | |
1 | 2020-02-07 09:14:58 | announced | |
2 | 2020-06-15 02:57:39 | announced | 2020-06-15: Updated publication reference for PubMed record(s): 32514074. |
⏵ 3 | 2024-10-22 04:58:19 | announced | 2024-10-22: Updated project metadata. |
Publication List
Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A, Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol, 5(9):1119-1133(2020) [pubmed] |
10.1038/s41564-020-0736-7; |
Keyword List
curator keyword: Technical, Biomedical |
submitter keyword: target engagement, cathepsin inhibitor, Salmonella,thermal proteome profiling |
Contact List
Athanasios Typas |
contact affiliation | European Molecular Biology Laboratory |
contact email | typas@embl.de |
lab head | |
Andre Mateus |
contact affiliation | European Molecular Biology Laboratory |
contact email | andre.mateus@embl.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD016086
- Label: PRIDE project
- Name: Thermal proteome profiling in of CA-074me