PXD016086

PXD016086 is an original dataset announced via ProteomeXchange.

Title	Thermal proteome profiling in of CA-074me
Description	We performed thermal proteome profiling (TPP) to study changes to protein thermal stability and abundance of CA-074me (cathepsin inhibitor) in RAW264.7 macrophages after Salmonella typhimurium infection.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:58:13.336.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andre Mateus
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); NCBI TaxID: 99287;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-31 01:20:59	ID requested
1	2020-02-07 09:14:58	announced
2	2020-06-15 02:57:39	announced	2020-06-15: Updated publication reference for PubMed record(s): 32514074.
⏵ 3	2024-10-22 04:58:19	announced	2024-10-22: Updated project metadata.

Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A, Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol, 5(9):1119-1133(2020) [pubmed]

10.1038/s41564-020-0736-7;

curator keyword: Technical, Biomedical

submitter keyword: target engagement, cathepsin inhibitor, Salmonella,thermal proteome profiling

Athanasios Typas
contact affiliation	European Molecular Biology Laboratory
contact email	typas@embl.de
lab head
Andre Mateus
contact affiliation	European Molecular Biology Laboratory
contact email	andre.mateus@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD016086

PRIDE project URI

• PRIDE
  1. PXD016086
     1. Label: PRIDE project
     2. Name: Thermal proteome profiling in of CA-074me