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PXD016086

PXD016086 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThermal proteome profiling in of CA-074me
DescriptionWe performed thermal proteome profiling (TPP) to study changes to protein thermal stability and abundance of CA-074me (cathepsin inhibitor) in RAW264.7 macrophages after Salmonella typhimurium infection.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:58:13.336.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndre Mateus
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); NCBI TaxID: 99287;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-10-31 01:20:59ID requested
12020-02-07 09:14:58announced
22020-06-15 02:57:39announced2020-06-15: Updated publication reference for PubMed record(s): 32514074.
32024-10-22 04:58:19announced2024-10-22: Updated project metadata.
Publication List
Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A, Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol, 5(9):1119-1133(2020) [pubmed]
10.1038/s41564-020-0736-7;
Keyword List
curator keyword: Technical, Biomedical
submitter keyword: target engagement, cathepsin inhibitor, Salmonella,thermal proteome profiling
Contact List
Athanasios Typas
contact affiliationEuropean Molecular Biology Laboratory
contact emailtypas@embl.de
lab head
Andre Mateus
contact affiliationEuropean Molecular Biology Laboratory
contact emailandre.mateus@embl.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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