PXD016084
PXD016084 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ATG9A is a component of the ESCRT system and governs plasma membrane repair |
| Description | ATG9 is often described as the sole transmembrane protein among the core autophagy factors. The mammalian ATG9A is notorious for trafficking through numerous cellular compartments including the plasma membrane. The reasons for ATG9As wide intracellular distribution and its role at the PM are not fully understood. Here we show that ATG9A intimately interacts with components of the ESCRT system. Employing proteomic analyses with APEX2-ATG9A we identified a number of ESCRTs as ATG9A interactors, including TSG101 and ALIX, and uncovered cooperation between ATG9A and ESCRTs in protection against PM damage. ATG9A knockouts sensitized PM to permeabilization by a broad spectrum of agents including gasdermin and Mycobacterium tuberculosis. ESCRTs phenocopied ATG9A in protection against PM injury. Thus, in addition to its function in autophagy, ATG9A is a component of the ESCRT system engaged in the repair of PM |
| HostingRepository | MassIVE |
| AnnounceDate | 2021-07-15 |
| AnnouncementXML | Submission_2021-07-15_11:30:19.336.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Brett Phinney |
| SpeciesList | scientific name: homo; |
| ModificationList | Oxidation; Deamidated; Carbamidomethyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-10-30 18:13:19 | ID requested | |
| ⏵ 1 | 2021-07-15 11:30:19 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: ATG9, ATG9A, APEX2-ATG9A, ESCRT system, Plasma membrane |
Contact List
| Vojo Deretic | |
|---|---|
| contact affiliation | University of New Mexico Health Sciences Center |
| contact email | vderetic@salud.unm.edu |
| lab head | |
| Brett Phinney | |
| contact affiliation | UC Davis |
| contact email | brettsp@ucdavis.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084519/ |
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