PXD016029

PXD016029 is an original dataset announced via ProteomeXchange.

Title	Early urine proteome changes in an implanted bone cancer rat model
Description	In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group rats compared with the proteins in the urine of the control group rats; this was even the case when there were no significant lesions identified in the Computed Tomography(CT) examination. Among these differentially proteins, 7 were reported to be associated with tumor bone metastasis. GO analysis shows that the differential proteins on day 3 were involved in several responses, including the acute phase response, the adaptive immune response and the innate immune response. The differentially proteins on day 7 were involved in the mineral absorption pathway. The differentially proteins on day 13 were involved in vitamin D binding and calcium ion binding. These processes may be associated with bone metastasis. Our results demonstrate that urine could sensitively reflect the changes in the early stage of implanted bone cancer; this provides valuable clues for future studies of urine biomarkers for tumor bone metastasis.
HostingRepository	iProX
AnnounceDate	2019-10-25
AnnouncementXML	Submission_2020-11-29_23:36:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Weiwei Qin
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-26 05:57:47	ID requested
⏵ 1	2020-11-29 23:36:34	announced

Wang T, Li L, Qin W, Gao Y, Early urine proteome changes in an implanted bone cancer rat model. Bone Rep, 12():100238(2020) [pubmed]

submitter keyword: biomarkers, urine proteome, Walker 256 cells, implanted bone cancer rat model.

Youhe Gao
contact affiliation	Beijing Normal University
contact email	gaoyouhe@bnu.edu.cn
lab head
Weiwei Qin
contact affiliation	Beijing Normal University
contact email	dyqinweiwei@163.com
dataset submitter

iProX dataset URI