PXD015994

PXD015994 is an original dataset announced via ProteomeXchange.

Title	DeSUMOylase SENP7 mediated epithelial signaling triggers intestinal inflammation via expansion of Gamma-delta T cell
Description	Inflammatory bowel disease (IBD) is a complex autoimmune disorder and recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here we have identified a link between De-SUMOylases and tissue inflammation in IBD. SENP7, a deSUMOylase was seen to be explicitly upregulatedupregulated specifically in intestinal epithelial cells of animal model and human IBD patient samples. SENP7 expression was negatively regulated by a direct interaction and ubiquitination by SIAH2. This control was lost in inflamed cells, leading to SENP7 upregulation allowing access to a distinct SENP7 interactome revealed by complex mass-spectrometry. Furthermore, in vivo Knock-Down of SENP7 or pharmacological induction of SIAH2 abrogated DSS-induced gut inflammation. Explicitly, SENP7 upregulation led to an expansion of localized γδT cells triggering a proinflammatory environment. Strong statistical correlation between upregulated SENP7 and high clinical disease indices were observed in IBD patients. Overall our data reveal that epithelial SENP7 is necessary and sufficient in controlling gut inflammation, thus highlighting its importance as a potential drug target.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_07:35:45.062.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	CV srikanth
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	carbamoylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-24 02:00:11	ID requested
⏵ 1	2025-05-06 07:35:45	announced

10.1016/j.celrep.2019.11.028;

Suhail A, Rizvi ZA, Mujagond P, Ali SA, Gaur P, Singh M, Ahuja V, Awasthi A, Srikanth CV, DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells. Cell Rep, 29(11):3522-3538.e7(2019) [pubmed]

submitter keyword: deSUMOylases, PTMs, SUMOylation,inflammation, Proteomics

Dr. C. V. Srikanth
contact affiliation	Regional Centre for Biotechnology, 3rd milestone Gurgaon Faridabad Expressway 121001, Faridabad INDIA, 0129-2848820, 0129-2848800
contact email	cvsrikanth90@gmail.com
lab head
CV srikanth
contact affiliation	Regional Center for Biotechnology
contact email	cvsrikanth90@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015994
     1. Label: PRIDE project
     2. Name: DeSUMOylase SENP7 mediated epithelial signaling triggers intestinal inflammation via expansion of Gamma-delta T cell