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PXD015979 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics pinpoint alterations in grade I meningiomas of male versus female patients
DescriptionMeningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells. Risk factors for the disease include exposure to ionizing radiation, head trauma, and family history. Surgery is the first option of treatment for meningioma, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Literature shown several specific unfoldings of this disease when comparing male versus female patients; for example, in one hand, its incidence is higher in female patients, on the other hand, male patients usually develop the malignant and more aggressive type. Here, we compare the proteomic profile of tumor biopsies of male and female patients diagnosed with grade I meningioma and list several differentially abundant proteins between the two groups that ultimately reflected in different enriched pathways. For male patients, the enriched pathways were mostly involved in neutrophil degranulation, cell-matrix organization, antigen processing, and the presentation of exogenous peptides; for the female group, pathways related to the organization of cellular components and organelles, and RNA splicing. Tackling on these differences is important to better understand this disease and, ultimately, provide individual treatments.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJuliana Fischer
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-10-23 01:29:14ID requested
12020-06-30 04:03:57announced
Publication List
Silva JM, Wippel HH, Santos MDM, Verissimo DCA, Santos RM, Nogueira FCS, Passos GAR, Sprengel SL, Borba LAB, Carvalho PC, Fischer JSDG, Proteomics pinpoints alterations in grade I meningiomas of male versus female patients. Sci Rep, 10(1):10335(2020) [pubmed]
Keyword List
submitter keyword: grade I meningioma, gender comparison, mass spectrometry, shotgun proteomics
Contact List
Paulo Costa Carvalho
contact affiliationLaboratory of Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz – ParanĂ¡, Brazil;
contact emailpaulo@pcarvalho.com
lab head
Juliana Fischer
contact affiliationFiocruz
contact emailjulifr@gmail.com
dataset submitter
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