PXD015979

PXD015979 is an original dataset announced via ProteomeXchange.

Title	Proteomics pinpoint alterations in grade I meningiomas of male versus female patients
Description	Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells. Risk factors for the disease include exposure to ionizing radiation, head trauma, and family history. Surgery is the first option of treatment for meningioma, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Literature shown several specific unfoldings of this disease when comparing male versus female patients; for example, in one hand, its incidence is higher in female patients, on the other hand, male patients usually develop the malignant and more aggressive type. Here, we compare the proteomic profile of tumor biopsies of male and female patients diagnosed with grade I meningioma and list several differentially abundant proteins between the two groups that ultimately reflected in different enriched pathways. For male patients, the enriched pathways were mostly involved in neutrophil degranulation, cell-matrix organization, antigen processing, and the presentation of exogenous peptides; for the female group, pathways related to the organization of cellular components and organelles, and RNA splicing. Tackling on these differences is important to better understand this disease and, ultimately, provide individual treatments.
HostingRepository	PRIDE
AnnounceDate	2020-06-30
AnnouncementXML	Submission_2020-06-30_04:03:56.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juliana Fischer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-23 01:29:14	ID requested
⏵ 1	2020-06-30 04:03:57	announced

Silva JM, Wippel HH, Santos MDM, Verissimo DCA, Santos RM, Nogueira FCS, Passos GAR, Sprengel SL, Borba LAB, Carvalho PC, Fischer JSDG, Proteomics pinpoints alterations in grade I meningiomas of male versus female patients. Sci Rep, 10(1):10335(2020) [pubmed]

submitter keyword: grade I meningioma, gender comparison, mass spectrometry, shotgun proteomics

Paulo Costa Carvalho
contact affiliation	Laboratory of Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz – Paraná, Brazil;
contact email	paulo@pcarvalho.com
lab head
Juliana Fischer
contact affiliation	Fiocruz
contact email	julifr@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD015979

PRIDE project URI

• PRIDE
  1. PXD015979
     1. Label: PRIDE project
     2. Name: Proteomics pinpoint alterations in grade I meningiomas of male versus female patients