PXD015972
PXD015972 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Changes to the TDP43 and FUS Interactomes Induced by DNA Damage |
| Description | The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic cause for amyotrophic lateral sclerosis (ALS) and TDP-43 proteopathies are found in nearly all ALS patients. Both the natural function and contribution to pathology for TDP-43 remains unclear. The intersection of functions between TDP-43 and FUS can focus attention for those natural functions mostly likely to be relevant to disease. Here we compare the role played by TDP-43 and FUS maintaining chromatin stability for dividing HEK293T cells. We also determine and compare the interactomes of TDP-43 and FUS, quantitating changes in those before and after DNA damage. Finally, selected interactions with known importance to DNA damage repair were validated by co-immunoprecipitation assays. This study uncovered TDP-43 and FUS binding to several factors important to DNA repair mechanisms that can be either replication dependent, independent, or both. These results support recently published findings about the role TDP-43 plays in DNA repair and provide new ways that TDP-43 can bind the machinery that guard DNA integrity in cells. |
| HostingRepository | MassIVE |
| AnnounceDate | 2019-10-22 |
| AnnouncementXML | Submission_2019-10-22_13:58:04.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jacob Schwartz |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-10-22 12:06:15 | ID requested | |
| ⏵ 1 | 2019-10-22 13:58:05 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: TDP-43, FUS, DNA damage repair, transcription, amyotrophic lateral sclerosis, frontal temporal dementia |
Contact List
| Jacob Schwartz | |
|---|---|
| contact affiliation | University of Arizona |
| contact email | jcschwartz@email.arizona.edu |
| lab head | |
| Jacob Schwartz | |
| contact affiliation | University of Arizona |
| contact email | jcschwartz@email.arizona.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084486/ |
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