PXD015938

PXD015938 is an original dataset announced via ProteomeXchange.

Title	Data in support of plasma proteomics study forearly markers of antibiotics dependent necrotising enterocolitis in preterm pigs
Description	Most hospitalized preterm infants receive antibiotics (AB) in the first days of life to treat or prevent systemic infections. Short-term, early AB treatment may also prevent against the microbiota-dependent serious gut disorder, necrotising enterocolitis (NEC). However, it remains a challenge to predict or early detection of NEC in the first weeks of life and few diagnostic markers exist. Using preterm piglets as models for infants, we hypothesised that proteomic profiling could be used to identify new early plasma biomarkers of NEC with or without prior AB treatment. Preterm newborn pigs were treated with saline (CON) or antibiotics (ampicillin, gentamicin, and metronidazole), given enterally (ENT) or parenterally (PAR), and fed formula for four days to induce NEC. The gut was collected for scoring of NEC lesions and blood was collected for haematology and plasma proteomics
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:26:19.988.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Allan Stensballe
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-21 04:14:37	ID requested
1	2021-09-08 11:31:32	announced
⏵ 2	2024-10-22 05:26:22	announced	2024-10-22: Updated project metadata.

10.3389/fimmu.2020.565862;

Jiang YN, Muk T, Stensballe A, Nguyen DN, Sangild PT, Jiang PP, Early Protein Markers of Necrotizing Enterocolitis in Plasma of Preterm Pigs Exposed to Antibiotics. Front Immunol, 11():565862(2020) [pubmed]

submitter keyword: antibiotics, NEC, plasma,pig

Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
lab head
Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015938
     1. Label: PRIDE project
     2. Name: Data in support of plasma proteomics study forearly markers of antibiotics dependent necrotising enterocolitis in preterm pigs