PXD015850

PXD015850 is an original dataset announced via ProteomeXchange.

Title	Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome
Description	Proteins in saliva are needed for preprocessing food in the mouth, maintenance of tooth mineralization, and protection from microbial pathogens. Novel insights into human lineage-specific functions of salivary proteins and clues to their involvement in human disease can be gained through evolutionary studies, as recently shown for salivary amylase AMY1 and salivary agglutinin deleted in malignant brain tumors 1/gp340. However, the entirety of proteins in saliva, the 20 salivary proteome, has not yet been investigated from an evolutionary perspective. Here, we compared the proteomes of human saliva and the saliva of our closest extant evolutionary relatives, chimpanzees and gorillas, using macaques as an outgroup, with the aim to uncover features in saliva protein composition that are unique to each species.We found that humans produce a waterier saliva, containing less than half total protein than great apes and OldWorldmonkeys. For all major salivary proteins in humans, we could identify counterparts in chimpanzee and gorilla saliva. However, we 25 discovered unique protein profiles in saliva of humans that were distinct from those of nonhuman primates. These findings open up the possibility that dietary differences and pathogenic pressures may have shaped a distinct salivary proteome in the human lineage.
HostingRepository	PRIDE
AnnounceDate	2019-12-13
AnnouncementXML	Submission_2020-02-17_02:59:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Markus Hardt
SpeciesList	scientific name: Pan troglodytes (Chimpanzee); NCBI TaxID: 9598; scientific name: Macaca mulatta (Rhesus macaque); NCBI TaxID: 9544; scientific name: Gorilla gorilla; NCBI TaxID: 9593; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-16 02:35:11	ID requested
1	2019-12-13 01:43:24	announced
⏵ 2	2020-02-17 02:59:29	announced	2020-02-17: Updated publication reference for PubMed record(s): 31614365.

Thamadilok S, Choi KS, Ruhl L, Schulte F, Kazim AL, Hardt M, Gokcumen O, Ruhl S, Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome. Mol Biol Evol, 37(2):395-405(2020) [pubmed]

submitter keyword: Saliva, Primates, Proteome

Markus Hardt
contact affiliation	The Forsyth Institute
contact email	mhardt@forsyth.org
lab head
Markus Hardt
contact affiliation	FORSYTH INSTITUTE
contact email	mhardt@forsyth.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD015850

PRIDE project URI

• PRIDE
  1. PXD015850
     1. Label: PRIDE project
     2. Name: Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome