PXD015789

PXD015789 is an original dataset announced via ProteomeXchange.

Title	The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
Description	The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of the Warburg phenotype of cancer cells. However, others have reported the opposite and there is no consensus on the relevant TRAP1 interactors. This calls for a more comprehensive analysis of the TRAP1 interactome and of how TRAP1 and mitochondrial metabolism mutually affect each other.
HostingRepository	PRIDE
AnnounceDate	2020-01-16
AnnouncementXML	Submission_2020-01-16_00:43:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jon (Jian-Jiang) Hao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-11 01:17:49	ID requested
⏵ 1	2020-01-16 00:59:03	announced

Dataset with its publication pending

submitter keyword: HSP90, TRAP1, oxidative phosphorylation, glutamine, mitochondria, molecular chaperone, ATP synthase, Proteomics

Didier Picard
contact affiliation	Département de Biologie Cellulaire Université de Genève Sciences III 30, quai Ernest-Ansermet CH - 1211 Genève 4, Switzerland
contact email	didier.picard@unige.ch
lab head
Jon (Jian-Jiang) Hao
contact affiliation	Poochon Scientific
contact email	jon.hao@poochonscientific.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015789

PRIDE project URI

• PRIDE
  1. PXD015789
     1. Label: PRIDE project
     2. Name: The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis