PXD015772

PXD015772 is an original dataset announced via ProteomeXchange.

Title	eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine rich motifs in th 5'UTR
Description	Here we show eIF4A2 is a major effector of the represive miRNA pathway functioning via the Ccr4_Not complex; through its interaction with the Ccr4-Not complex eIF4A2 represses mRNAs at translation initiation. We show evidence that native eIF4A2 has similar properties to chemically inhibited eIF4A1. eIF4A2 exerts its repressive effect by binding purine-rich motifs which are enriched in the 5'UTR directly upstream of the AUG codon.
HostingRepository	PRIDE
AnnounceDate	2019-10-10
AnnouncementXML	Submission_2019-10-10_03:47:13.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015772
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rebekah Jukes-Jones
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-10 02:50:13	ID requested
⏵ 1	2019-10-10 03:47:14	announced

Dataset with its publication pending

submitter keyword: Translation, initiation, eIF4A2, DDX6, mRNA

Ania Wilczynska
contact affiliation	MRC Toxicology Unit Leicester Uni of Cambridge and Beatson Institute Glasgow
contact email	A.Wilczynska@beatson.gla.ac.uk
lab head
Rebekah Jukes-Jones
contact affiliation	MRC Toxicology Unit
contact email	rj396@mrc-tox.cam.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD015772

PRIDE project URI

• PRIDE
  1. PXD015772
     1. Label: PRIDE project
     2. Name: eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine rich motifs in th 5'UTR