PXD015742

PXD015742 is an original dataset announced via ProteomeXchange.

Title	Molecular basis of senescence transmitting in the population of human endometrial stromal cells
Description	Hormone-regulated proliferation and differentiation of endometrial stromal cells (ESCs) determine overall endometrial plasticity and receptivity to embryos. Previously we revealed that ESCs may undergo premature senescence, accompanied by proliferation loss and various intracellular alterations. Here we focused on whether and how senescence may be transmitted within the ESCs population. We revealed that senescent ESCs may induce paracrine senescence in young counterparts via cell contacts, secreted factors and extracellular vesicles. According to secretome-wide profiling we identified plasminogen activator inhibitor -1 (PAI-1) to be the most prominent protein secreted by senescent ESCs. By applying CRISPR/Cas9 techniques we disclosed that PAI-1 secreted by senescent ESCs may serve as the master-regulator of paracrine senescence progression within the ESCs population. Unraveled molecular basis of senescence transduction in the ESCs population may be further considered in terms of altered endometrial plasticity and sensitivity to invading embryo, thus contributing to the female infertility curing.
HostingRepository	PRIDE
AnnounceDate	2019-11-12
AnnouncementXML	Submission_2019-11-11_18:34:40.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015742
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Annarita Farina
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-08 07:39:05	ID requested
⏵ 1	2019-11-11 18:34:42	announced

Griukova A, Deryabin P, Shatrova A, Burova E, Severino V, Farina A, Nikolsky N, Borodkina A, Molecular basis of senescence transmitting in the population of human endometrial stromal cells. Aging (Albany NY), 11(21):9912-9931(2019) [pubmed]

submitter keyword: endometrial stromal cells, senescence, SASP, PAI-1

Annarita Farina
contact affiliation	Department of Medicine - University of Geneva
contact email	annarita.farina@translationalresearch.net
lab head
Annarita Farina
contact affiliation	University of Geneva
contact email	Annarita.Farina@translationalresearch.net
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD015742

PRIDE project URI

• PRIDE
  1. PXD015742
     1. Label: PRIDE project
     2. Name: Molecular basis of senescence transmitting in the population of human endometrial stromal cells