PXD015725

PXD015725 is an original dataset announced via ProteomeXchange.

Title	Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer
Description	The Wnt signaling pathway is playing a crucial role during development and adult tissue homeostasis. However, the tissue and cell type-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Proximity-dependent biotinylation assay (BioID) coupled with mass spectrometry identified transcriptional co-regulators required for FOXB2-dependent Wnt activation.
HostingRepository	PRIDE
AnnounceDate	2019-11-27
AnnouncementXML	Submission_2019-11-27_06:53:35.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015725
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lavanya Moparthi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-07 02:36:23	ID requested
1	2019-10-16 00:24:23	announced
2	2019-10-25 06:43:16	announced	2019-10-25: Updated publication reference for PubMed record(s): 31611391.
⏵ 3	2019-11-27 06:53:37	announced	2019-11-27: Updated project metadata.

Moparthi L, Pizzolato G, Koch S, Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer. Proc Natl Acad Sci U S A, 116(44):22189-22195(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: FOXB2, Wnt, differentiation, cancer

Dr.Stefan Koch
contact affiliation	Wallenberg Centre for Molecular Medicine (WCMM), Link??ping University, SE-581 85, Link??ping, Sweden Department of Clinical and Experimental Medicine (IKE), Faculty of Health Sciences, Link??ping University, SE-581 85, Link??ping, Sweden
contact email	stefan.koch@liu.se
lab head
Lavanya Moparthi
contact affiliation	LINK??PING UNIVERSITY
contact email	lavanya.moparthi@liu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD015725

PRIDE project URI

• PRIDE
  1. PXD015725
     1. Label: PRIDE project
     2. Name: Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer