PXD015651

PXD015651 is an original dataset announced via ProteomeXchange.

Title	Intracellular proteins adsorbed on AuNPs during transcytosis and exocytosis
Description	we set protein corona as the research object in this study, and focused on exploring the biological effects of intracellular protein corona (IPC) that formed on particle surface after transcytosis of nanomedicines. Considering the multi-functionalization characteristic, gold nanoparticles (AuNPs) were fabricated here as the model of nanomedicines. We established a dual-filtration proteomics strategy based on mass spectrometry (MS) to detect the composition and category of IPC after transcytosis. Based on the analysis on IPC proteins, we did achieve novel and significant findings.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:09:21.390.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mengmeng Qin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-10-01 02:01:49	ID requested
1	2020-01-20 01:09:07	announced
⏵ 2	2024-10-22 04:09:27	announced	2024-10-22: Updated project metadata.

Qin M, Zhang J, Li M, Yang D, Liu D, Song S, Fu J, Zhang H, Dai W, Wang X, Wang Y, He B, Zhang Q, Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions. Theranostics, 10(3):1213-1229(2020) [pubmed]

10.7150/thno.38900;

submitter keyword: transcytosis, exocytosis, protein corona,Caco-2, AuNPs

Mengmeng Qin
contact affiliation	School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
contact email	clqinmengmeng@pku.edu.cn
lab head
Mengmeng Qin
contact affiliation	Peking University
contact email	clqinmengmeng@pku.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015651

PRIDE project URI

• PRIDE
  1. PXD015651
     1. Label: PRIDE project
     2. Name: Intracellular proteins adsorbed on AuNPs during transcytosis and exocytosis